Recently, patients with tobacco smoke induced emphysema have been shown to exhibit
classical signs of T cell mediated autoimmunity characterized by autoantibody production …

COPD is a leading cause of death worldwide, with acute exacerbations being a major
contributor to disease morbidity and mortality. Indeed, exacerbations are associated with …

Naringin is a flavanone with various bioactivities including expectorant effect, antitussive
effect and inhibitory effects on asthma and acute lung injury. In present study we examined …

Background Small airways disease (SAD) is a key component of COPD and is a main
contributing factor to lung function decline. Research Question Is SAD a key feature of …

Toxicogenomics opens novel opportunities for hazard assessment by utilizing computational
methods to map molecular events and biological processes. In this study, the transcriptomic …

Background Glucocorticoid functions are markedly impaired in patients with chronic
obstructive pulmonary disease (COPD). The phosphodiesterase 4 inhibitor roflumilast N …

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the
US and a major worldwide healthcare problem. The pathophysiologic mechanisms that …

Obstructive airway diseases such as asthma and chronic obstructive pulmonary disease
(COPD) are major global health issues. Although considered as distinct diseases, airway …

This study examined the pharmacologic characterization of CHF6001 [(S)-3, 5-dichloro-4-(2-
(3-(cyclopropylmethoxy)-4-(difluoromethoxy) phenyl)-2-(3-(cyclopropylmethoxy)-4 …

Neutrophil migration into the airways is an important process to fight infection and is
mediated by cell adhesion molecules. The intercellular adhesion molecules, ICAM-1 (CD54) …