The underlying reasons for variable clinical outcomes from respiratory viral infections remain
uncertain. Several studies suggest that environmental factors contribute to this variation, but …

We have investigated the contribution of individual phosphoinositide 3-kinase (PI3K) Class I
isoforms to the regulation of neutrophil survival using (i) a panel of commercially available …

ROS production is an important effector mechanism mediating intracellular killing of
microbes by phagocytes. Inappropriate or untimely ROS production can lead to tissue …

Small animal models of chronic obstructive pulmonary disease (COPD) have several
limitations for identifying new therapeutic targets and biomarkers for human COPD. These …

Therapies involving elevation of the endogenous suppressor cyclic AMP (cAMP) are
currently used in the treatment of several chronic inflammatory disorders, including chronic …

Adenosine is a signaling nucleoside that is generated in response to cellular injury and
orchestrates the balance between tissue protection and the progression to pathological …

Abstract Phosphodiesterase 4 (PDE4) inhibitors are used to treat autoimmune and
inflammatory diseases, such as psoriasis and chronic obstructive pulmonary disease …

Aim of the study Asthma is an ailment of airways characterized by activation of the T helper
(Th) 2 lymphocytes and subsequent movement of inflammatory cells. Boerhavia …

Ethnopharmacological relevance Pseudolysimachion rotundum var. subintegrum
(Speedwell, Plantaginaceae) is used as a traditional herbal medicine for treating bronchitis …

Severe asthma comprises only 5% of patients with asthma, but the burden it brings to the
social health system accounts for more than half of all asthmatics. Clinical evidence shows …