Cytokines are pleiotropic molecules with important roles in inflammatory responses. Pro-
inflammatory cytokines and neuroinflammation are important not only in inflammatory …

Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Ethnopharmacological relevance According to traditional Chinese medicine (TCM) theory
(Yi Xue Zheng Zhuan), the main factors associated with the pathogenesis of depression are …

This study aimed to prepare and characterize chitosan-Transfersulin (CTI) as an effective
intranasal drug delivery system (IDDS) for the treatment of memory disorders by mediating …

With rapid aging of the population worldwide, the number of people with dementia is
dramatically increasing. Some studies have emphasized that metabolic syndrome, which …

Cannabidiol (CBD), a phytocannabinoid compound, presents antidepressant and anxiolytic-
like effects in the type-1 diabetes mellitus (DM1) animal model. Although the underlying …

Background Abundant evidence suggests that the prevalence and risk of depression in
people with diabetes is high. However, the pathogenesis of diabetes-related depression …

Aims Diabetes mellitus (DM), a chronic metabolic disease, is associated with behavioral
deficits. It has been suggested that ellagic acid (EA), a natural polyphenol compound, has …

Diabetes is a chronic and progressive syndrome commonly associated with several
neuropsychiatric comorbities, of which depression is the most studied. The prevalence of …

The critical factor considered in a depression induced by diabetes is the inflammation
eliciting hippocampal, amygdala and thalamic neuronal injury. Therefore, inhibiting …