Accelerated brain aging predicts impaired cognitive performance and greater disability in geriatric but not midlife adult depression
Depression is associated with markers of accelerated aging, but it is unclear how this
relationship changes across the lifespan. We examined whether a brain-based measure of …
relationship changes across the lifespan. We examined whether a brain-based measure of …
A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD
DNA methylation patterns at specific cytosine-phosphate-guanine (CpG) sites predictably
change with age and can be used to derive “epigenetic age”, an indicator of biological age …
change with age and can be used to derive “epigenetic age”, an indicator of biological age …
Linking the biological underpinnings of depression: role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and …
G Anderson - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
The pathophysiological underpinnings of neuroprogressive processes in recurrent major
depressive disorder (rMDD) are reviewed. A wide array of biochemical processes underlie …
depressive disorder (rMDD) are reviewed. A wide array of biochemical processes underlie …
Telomere length in newborns is related to maternal stress during pregnancy
TS Send, M Gilles, V Codd, I Wolf, S Bardtke… - …, 2017 - nature.com
Telomere length (TL) is a marker of biological aging, and numerous studies have shown
associations between TL and somatic or psychiatric disorders. Research also indicates an …
associations between TL and somatic or psychiatric disorders. Research also indicates an …
Transdiagnostic evaluation of epigenetic age acceleration and burden of psychiatric disorders
N Yusupov, L Dieckmann, M Erhart, S Sauer… - …, 2023 - nature.com
Different psychiatric disorders as well as exposure to adverse life events have individually
been associated with multiple age-related diseases and mortality. Age acceleration in …
been associated with multiple age-related diseases and mortality. Age acceleration in …
Telomere shortening and psychiatric disorders: a systematic review
PA Pousa, RM Souza, PHM Melo, BHM Correa… - Cells, 2021 - mdpi.com
Telomeres are aging biomarkers, as they shorten while cells undergo mitosis. The aim of
this study was to evaluate whether psychiatric disorders marked by psychological distress …
this study was to evaluate whether psychiatric disorders marked by psychological distress …
[HTML][HTML] The pediatric buccal epigenetic clock identifies significant ageing acceleration in children with internalizing disorder and maltreatment exposure
F Dammering, J Martins, K Dittrich, D Czamara… - Neurobiology of …, 2021 - Elsevier
Background Studies reporting accelerated ageing in children with affective disorders or
maltreatment exposure have relied on algorithms for estimating epigenetic age derived from …
maltreatment exposure have relied on algorithms for estimating epigenetic age derived from …
Telomeres as integrative markers of exposure to stress and adversity: a systematic review and meta-analysis
Telomeres have been proposed as a biomarker that integrates the impacts of different kinds
of stress and adversity into a common currency. There has as yet been no overall …
of stress and adversity into a common currency. There has as yet been no overall …
Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies
The aim of the present study was to map and grade evidence for the relationships between
telomere length with a diverse range of health outcomes, using an umbrella review of …
telomere length with a diverse range of health outcomes, using an umbrella review of …