BACKGROUND Chronic pain and opioid consumption may trigger diffuse hyperalgesia, but
their relative contributions to pain vulnerability remain unclear. OBJECTIVES To assess …

For 2 weeks following surgery, 55 patients with preexisting chronic pain (CP) reported daily
postoperative pain with movement and at rest. Of these, 30 CP patients used opioid …

Background In healthy individuals slow temporal summation of pain or wind-up (WU) can be
evoked by repetitive heat-pulses at frequencies of≥. 33 Hz. Previous WU studies have used …

Opioid abuse has continued to increase at an alarming rate since the 1990 s. As
documented by different medical specialties, medical boards, advocacy groups, and the …

Opioids have become the unequivocal therapy of choice in treating many varieties of chronic
pain. With the increased prescription of opioids, some unintended consequences have …

Objective. Opioids are frequently prescribed for chronic low back pain (CLBP), but there are
broad individual differences in the benefits and risks of opioid therapy, including the …

The major therapeutic challenge in inflammatory rheumatic diseases is the persistence of
pain despite good responses to specific therapies. Central sensitization, which can be …

Opioids may enhance pain sensitivity resulting in opioid-induced hyperalgesia (OIH).
Activation of spinal cyclooxygenase may play a role in the development of OIH. The aim of …

This study employed quantitative sensory testing (QST) to evaluate pain responses in
chronic spinal pain patients at low risk and high risk for opioid misuse, with risk classification …

Chronic opioid therapy (COT) for chronic non-cancer pain is frequently debated, and its
effectiveness is unproven in sickle cell disease (SCD). The authors conducted a descriptive …