Objective: The clinical relevance of pro-and hyperalgesic effects of opioids is still a matter of
debate. Particularly for remifentanil, an increased postoperative need for analgesics has …

In this issue of the British Journal of Anaesthesia, Comelon and colleagues1 report that
gradual withdrawal of remifentanil infusion may prevent opioid-induced hyperalgesia in …

The preprotachykinin A gene (ppt-A) codes for Substance P (SP), supports nociceptive
sensitization, and modulates inflammatory responses after incision. Repeated opioid use …

Objective To evaluate long-term changes in pain management strategies and assess the
outcomes of opioids and non-opioid combination analgesics after dental extractions …

Despite being a generally successful procedure, pain following reverse total shoulder
arthroplasty (rTSA) is a known complication. The aim of this systematic review is to identify …

Introduction Sickle cell disease (SCD) is an inherited blood disorder characterized by
abnormally shaped sickle cells. The hallmark of this disease is intermittent, painful vaso …

To predict sufentanil requirement for postoperative pain con... : Medicine To predict sufentanil
requirement for postoperative pain control using a real-time method: A prospective observational …

Background and Objectives: The effects of midazolam, a benzodiazepine, on pain
perception are complex on both spinal and supraspinal levels. It is not yet known whether …

What Do We Know About Opioid-Induced Hyperalgesia? | Journal of Clinical Outcomes
Management Skip to main content Home Journal of Clinical Outcomes Management ALL …