Porcine epidemic diarrhea virus: An updated overview of virus epidemiology, virulence variation patterns and virus–host interactions

Y Zhang, Y Chen, J Zhou, X Wang, L Ma, J Li, L Yang… - Viruses, 2022 - mdpi.com
The porcine epidemic diarrhea virus (PEDV) is a member of the coronavirus family, causing
deadly watery diarrhea in newborn piglets. The global pandemic of PEDV, with significant …

Multiple modes of protein–protein interactions promote RNP granule assembly

T Mittag, R Parker - Journal of molecular biology, 2018 - Elsevier
Eukaryotic cells are known to contain a wide variety of RNA–protein assemblies, collectively
referred to as RNP granules. RNP granules form from a combination of RNA–RNA, protein …

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

Z Deng, J Lim, Q Wang, K Purtell, S Wu, GM Palomo… - Autophagy, 2020 - Taylor & Francis
Macroautophagy (autophagy) is a key catabolic pathway for the maintenance of proteostasis
through constant digestion of selective cargoes. The selectivity of autophagy is mediated by …

Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

N Kedersha, G Stoecklin, M Ayodele… - The Journal of cell …, 2005 - rupress.org
Stress granules (SGs) are cytoplasmic aggregates of stalled translational preinitiation
complexes that accumulate during stress. GW bodies/processing bodies (PBs) are distinct …

Chromatin and beyond: the multitasking roles for SIRT6

S Kugel, R Mostoslavsky - Trends in biochemical sciences, 2014 - cell.com
In recent years there has been a large expansion in our understanding of SIRT6 biology
including its structure, regulation, biochemical activity, and biological roles. SIRT6 functions …

P bodies and the control of mRNA translation and degradation

R Parker, U Sheth - Molecular cell, 2007 - cell.com
Recent results indicate that many untranslating mRNAs in somatic eukaryotic cells assemble
into related mRNPs that accumulate in specific cytoplasmic foci referred to as P bodies …

Stress granules: the Tao of RNA triage

P Anderson, N Kedersha - Trends in biochemical sciences, 2008 - cell.com
Cytoplasmic RNA structures such as stress granules (SGs) and processing bodies (PBs) are
functional byproducts of mRNA metabolism, sharing substrate mRNA, dynamic properties …

RNA granules: post-transcriptional and epigenetic modulators of gene expression

P Anderson, N Kedersha - Nature reviews Molecular cell biology, 2009 - nature.com
The composition of cytoplasmic messenger ribonucleoproteins (mRNPs) is determined by
their nuclear and cytoplasmic histories and reflects past functions and future fates. The …

YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1

SP Somasekharan, A El-Naggar, G Leprivier… - Journal of Cell …, 2015 - rupress.org
Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is
to sequester and silence mRNAs in ribonucleoprotein complexes known as stress granules …

RNA granules

P Anderson, N Kedersha - The Journal of cell biology, 2006 - rupress.org
Cytoplasmic RNA granules in germ cells (polar and germinal granules), somatic cells (stress
granules and processing bodies), and neurons (neuronal granules) have emerged as …