Recent results indicate that many untranslating mRNAs in somatic eukaryotic cells assemble
into related mRNPs that accumulate in specific cytoplasmic foci referred to as P bodies …

Cytoplasmic RNA granules in germ cells (polar and germinal granules), somatic cells (stress
granules and processing bodies), and neurons (neuronal granules) have emerged as …

TIA-1 is an RNA binding protein that promotes the assembly of stress granules (SGs),
discrete cytoplasmic inclusions into which stalled translation initiation complexes are …

Stress granules (SGs) are RNA-containing cytoplasmic foci formed in response to stress
exposure. Since their discovery in 1999, over 120 proteins have been described to be …

Poly (ADP-ribose) is a major regulatory macromolecule in the nucleus, where it regulates
transcription, chromosome structure, and DNA damage repair. Functions in the interphase …

Angiogenin (ANG) is a secreted ribonuclease that cleaves tRNA to initiate a stress-response
program in mammalian cells. Here we show that ANG inhibits protein synthesis and …

Two prominent cytoplasmic RNA granules, ubiquitous RNA-processing bodies (PB) and
inducible stress granules (SG), regulate mRNA translation and are intimately related. In this …

Liquid-liquid phase separation (LLPS) of proteins that leads to formation of membrane-less
organelles is critical to many biochemical processes in the cell. However, dysregulated …

When confronted with environmental stress, cells either activate defence mechanisms to
survive, or initiate apoptosis, depending on the type of stress. Certain types of stress, such …

In contrast to other cytotoxic agents including anthracyclins and oxaliplatin (OXP), cisplatin
(CDDP) fails to induce immunogenic tumor cell death that would allow to stimulate an …