Fetal cerebrovascular responses to acute hypoxia are fundamentally different from those
observed in the adult cerebral circulation. The magnitude of hypoxic vasodilatation in the …

PREGNANCY IS A COMPLEX PHYSIOLOGICAL condition that involves the integration of a
variety of regulatory and organ systems. Many aspects of maternal and fetal adaptations …

In lung vasculature, reversible constriction of smooth muscle cells exists in response to
acute decrease in oxygen levels (hypoxia). Progressive and irreversible structural …

This review focuses on new insights provided by gene-modified animals into the
cardiovascular pharmacology of serotonin. During their development, mice mutant for …

The present study tests the hypothesis that age-related differences in contractility of cerebral
arteries from hypoxic animals involve changes in myofilament Ca2+ sensitivity. Basilar …

In the chicken embryo, acute hypoxemia results in cardiovascular responses, including an
increased peripheral resistance. We investigated whether local direct effects of decreased …

Cytosolic Ca2+ signaling dynamics are important to pulmonary arterial reactivity, and
alterations are implicated in pulmonary vascular disorders. Yet, adaptations in cellular Ca2+ …

To address the hypothesis that maturation alters the contribution of K-channels to resting
and agonist-induced tone in small cerebral arteries, second branch middle cerebral arteries …

For more than three decades, research programs in the Center of Perinatal Biology have
focused on the vascular biology of the fetal cerebral circulation. In the 1980s, research in the …

In light of observations that cerebrovascular levels of cGMP vary during maturation, the
present study examines the possibility that the mechanisms mediating cGMP-induced …