Hypoxic regulation of the fetal cerebral circulation
W Pearce - Journal of applied physiology, 2006 - journals.physiology.org
Fetal cerebrovascular responses to acute hypoxia are fundamentally different from those
observed in the adult cerebral circulation. The magnitude of hypoxic vasodilatation in the …
observed in the adult cerebral circulation. The magnitude of hypoxic vasodilatation in the …
Maternal and fetal adaptations during pregnancy: lessons in regulatory and integrative physiology
JP Granger - American Journal of Physiology-Regulatory …, 2002 - journals.physiology.org
PREGNANCY IS A COMPLEX PHYSIOLOGICAL condition that involves the integration of a
variety of regulatory and organ systems. Many aspects of maternal and fetal adaptations …
variety of regulatory and organ systems. Many aspects of maternal and fetal adaptations …
Functions of serotonin in hypoxic pulmonary vascular remodeling
JM Esteve, JM Launay, O Kellermann… - Cell biochemistry and …, 2007 - Springer
In lung vasculature, reversible constriction of smooth muscle cells exists in response to
acute decrease in oxygen levels (hypoxia). Progressive and irreversible structural …
acute decrease in oxygen levels (hypoxia). Progressive and irreversible structural …
Contribution of gene-modified mice and rats to our understanding of the cardiovascular pharmacology of serotonin
L Monassier, MA Laplante, T Ayadi, S Doly… - Pharmacology & …, 2010 - Elsevier
This review focuses on new insights provided by gene-modified animals into the
cardiovascular pharmacology of serotonin. During their development, mice mutant for …
cardiovascular pharmacology of serotonin. During their development, mice mutant for …
Chronic hypoxia modulates relations among calcium, myosin light chain phosphorylation, and force differently in fetal and adult ovine basilar arteries
SM Nauli, JM Williams… - Journal of applied …, 2005 - journals.physiology.org
The present study tests the hypothesis that age-related differences in contractility of cerebral
arteries from hypoxic animals involve changes in myofilament Ca2+ sensitivity. Basilar …
arteries from hypoxic animals involve changes in myofilament Ca2+ sensitivity. Basilar …
Direct effects of acute hypoxia on the reactivity of peripheral arteries of the chicken embryo
K Ruijtenbeek, CGA Kessels… - American Journal …, 2002 - journals.physiology.org
In the chicken embryo, acute hypoxemia results in cardiovascular responses, including an
increased peripheral resistance. We investigated whether local direct effects of decreased …
increased peripheral resistance. We investigated whether local direct effects of decreased …
Maturation of intracellular calcium homeostasis in sheep pulmonary arterial smooth muscle cells
R Goyal, KD Creel, E Chavis… - … of Physiology-Lung …, 2008 - journals.physiology.org
Cytosolic Ca2+ signaling dynamics are important to pulmonary arterial reactivity, and
alterations are implicated in pulmonary vascular disorders. Yet, adaptations in cellular Ca2+ …
alterations are implicated in pulmonary vascular disorders. Yet, adaptations in cellular Ca2+ …
Maturation alters the contribution of potassium channels to resting and 5HT-induced tone in small cerebral arteries of the sheep
GQ Teng, SM Nauli, JE Brayden, WJ Pearce - Developmental brain …, 2002 - Elsevier
To address the hypothesis that maturation alters the contribution of K-channels to resting
and agonist-induced tone in small cerebral arteries, second branch middle cerebral arteries …
and agonist-induced tone in small cerebral arteries, second branch middle cerebral arteries …
The fetal cerebral circulation: three decades of exploration by the LLU center for perinatal biology
WJ Pearce - Advances in Fetal and Neonatal Physiology …, 2014 - Springer
For more than three decades, research programs in the Center of Perinatal Biology have
focused on the vascular biology of the fetal cerebral circulation. In the 1980s, research in the …
focused on the vascular biology of the fetal cerebral circulation. In the 1980s, research in the …
Effects of maturation on mechanisms of cGMP-induced cerebral vasodilatation
SM Nauli, JM Williams, WJ Pearce - Developmental Neuroscience, 2001 - karger.com
In light of observations that cerebrovascular levels of cGMP vary during maturation, the
present study examines the possibility that the mechanisms mediating cGMP-induced …
present study examines the possibility that the mechanisms mediating cGMP-induced …