As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

We have developed a new technique for proximity-dependent labeling of proteins in
eukaryotic cells. Named BioID for proximity-dependent biotin identification, this approach is …

The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …

The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet
during cell division, migration, and differentiation, it frequently moves to an asymmetric …

Growing evidence suggests that cytoplasmic actin filaments are essential factors in the
modulation of nuclear shape and function. However, the mechanistic understanding of the …

Increased mobility of chromatin surrounding double-strand breaks (DSBs) has been noted in
yeast and mammalian cells but the underlying mechanism and its contribution to DSB repair …

The nucleus is the defining feature of eukaryotic cells and often represents the largest
organelle. Over the past decade, it has become apparent that the nucleus is tightly …

During cell migration, the movement of the nucleus must be coordinated with the
cytoskeletal dynamics at the leading edge and trailing end, and, as a result, undergoes …

The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of outer and inner
nuclear membrane Klarsicht, ANC-1, and Syne homology (KASH) and Sad1 and UNC-84 …