Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

The prevalence of cerebrovascular disease increases with age, placing the elderly at a
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …

Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes
that occur in specific cell types have not been fully characterized. Here, we profile single …

Neurodegenerative diseases, the leading cause of morbidity and disability, are gaining
increased attention as they impose a considerable socioeconomic impact, due in part to the …

The adult quiescent blood–brain barrier (BBB), a structure organised by endothelial cells
through interactions with pericytes, astrocytes, neurons and microglia in the neurovascular …

Hypertension is a leading cause of stroke and dementia, effects attributed to disrupting
delivery of blood flow to the brain. Hypertension also alters the blood-brain barrier (BBB), a …

The blood-brain barrier (BBB) is a dynamic, highly selective barrier primarily formed by
endothelial cells connected by tight junctions that separate the circulating blood from the …

The endothelial cells that form the blood–brain barrier (BBB) are coated with glycocalyx, on
the luminal side, and with the basement membrane and astrocyte endfeet, on the abluminal …

Astrocytes comprise a heterogeneous cell population characterized by distinct
morphologies, protein expression and function. Unlike neurons, astrocytes do not generate …

Brain endothelial cells (BECs) are key constituents of the blood-brain barrier (BBB),
protecting the brain from pathogens and restricting access of circulatory factors. Yet …