Hematopoietic cancers are often initiated by deregulation of the transcriptional machinery.
Prominent among such regulators are the sequence-specific DNA-binding transcription …

Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV) associated tumor. In
addition to EBV, host genetic factors are believed to be important determinants of NPC risk …

Familial aggregation, coupled with ethnic variation in incidence, suggests that inherited
susceptibility plays a role in the development of lymphoma, and the search for genetic risk …

Age-at-onset traits are of paramount importance in studies of age-related diseases and
behavioral genetics. Cox mixed-effects models (CMEMs) are widely used when sample …

Recurrently mutated in lymphoid neoplasms, the transcription factor RFX7 is emerging as a
tumor suppressor. Previous reports suggested that RFX7 may also have a role in …

B-cell malignancies (BCM) originate from the same cell of origin, but at different maturation
stages and have distinct clinical phenotypes. Although genetic risk variants for individual …

The TERT-CLPTM1L region of chromosome 5p15. 33 is a multi-cancer susceptibility locus
that encodes the reverse transcriptase subunit, hTERT, of the telomerase enzyme …

Chronic lymphocytic leukemia (CLL) displays remarkable ethnic predisposition for whites,
with relative sparing of African-American and Asian populations. In addition, CLL displays …

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the West and is
an incurable malignancy. No firmly established evidence exists for environmental risk factors …

The analysis of developments in the incidence (new cases), com‑bined with mortality
(death), is an essential part of the processes of surveillance and observation of the …