Chronic alcohol induces subcircuit-specific striatonigral plasticity enhancing the sensorimotor basal ganglia role in action execution

G Sitzia, S Bariselli, A Gracias, DM Lovinger - Science Advances, 2024 - science.org
Functional deficits in basal ganglia (BG) circuits contribute to cognitive and motor
dysfunctions in alcohol use disorder. Chronic alcohol exposure alters synaptic function and …

Neurosteroid [3α, 5α]-3-Hydroxy-pregnan-20-one Enhances the CX3CL1-CX3CR1 Pathway in the Brain of Alcohol-Preferring Rats with Sex-Specificity

I Balan, A Grusca, SL Chéry, BR Materia, TK O'Buckley… - Life, 2024 - mdpi.com
This study investigates the impact of allopregnanolone ([3α, 5α] 3-hydroxypregnan-20-one
or 3α, 5α-tetrahydroprogesterone (3α, 5α-THP); 10 mg/kg, IP) on fractalkine/CX3-C motif …

Differences in brain network topology based on alcohol use history in adolescents

HA Kirse, M Bahrami, RG Lyday, SL Simpson… - Brain sciences, 2023 - mdpi.com
Approximately 6 million youth aged 12 to 20 consume alcohol monthly in the United States.
The effect of alcohol consumption in adolescence on behavior and cognition is heavily …

Chronic alcohol induces subcircuit-specific striatonigral plasticity shifting action control to the sensorimotor striatum

G Sitzia, S Bariselli, A Gracias, DM Lovinger - bioRxiv, 2023 - biorxiv.org
While cortico-striatal circuit deficits contribute to Alcohol Use Disorder, the impact of alcohol
on synaptic function in the basal ganglia output, the substantia nigra pars reticulata (SNr) …

Role of the Prefrontal Cortex to Dorsomedial Striatum Projections in Compulsive Alcohol Drinking

M Bauer - 2023 - scholarworks.iupui.edu
Compulsive alcohol drinking is a defining feature of alcohol use disorder and is
characterized as drinking alcohol despite knowledge of negative consequences. This …