Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience
community with recent discoveries of mutations in the gene for PGRN that cause …

Major discoveries have been made in the recent past in the genetics, biochemistry and
neuropathology of frontotemporal lobar degeneration (FTLD). TAR DNA‐binding protein 43 …

Ubiquitin-positive tau-negative neuronal cytoplasmic inclusions and dystrophic neurites are
common pathological features in frontotemporal lobar degeneration (FTLD) with or without …

Amyotrophic lateral sclerosis (ALS) is increasingly recognized to be a multisystem disorder
which includes both clinical and neuropathological features of a frontotemporal lobar …

TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of sporadic and
familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions …

We have investigated the extent and pattern of immunostaining for ubiquitin protein (UBQ) in
60 patients with frontotemporal lobar degeneration (FTLD) with ubiquitin-positive, tau …

Semantic dementia is a syndrome of progressive deterioration in semantic memory
(knowledge of objects, people, concepts and words). It falls within the clinical spectrum of …

The most common pathology in frontotemporal dementia (FTD) is tau-negative, ubiquitin-
immunoreactive (ub-ir) neuronal inclusions (FTLD-U). Recently, we identified mutations in …

We have investigated the extent and pattern of immunostaining for the TAR DNA-binding
protein, TDP-43, in 37 patients with frontotemporal lobar degeneration with ubiquitin (UBQ) …

TDP-43, a nuclear factor that functions in regulating transcription and alternative splicing,
was recently identified as a component of the ubiquitin-positive, tau-negative inclusions …