Diabetes can lead to serious microvascular complications like proliferative diabetic
retinopathy (PDR), which is the leading cause of blindness in adults. The proteomic changes …

purpose. To determine whether intraocular gene transfer of pigment epithelium-derived
factor (PEDF) protects the retina from ischemia-reperfusion injury. methods. Four days …

The normal cornea is devoid of lymphatic and blood vessels, thus suppressing both the
afferent (lymphatic) and efferent (vascular) arms of the immune response–contributing to its …

In many countries, photodynamic therapy (PDT) has been recognized as a standard
treatment for malignant conditions (for example, esophageal and lung cancers) and non …

We previously demonstrated that differentiated retinal pigment epithelial (RPE) cells express
high levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived …

Retinal vein occlusion (RVO) is one of the most common retinal vascular diseases. The
pathogenesis of RVO is multifactorial and involves a complex interplay among a variety of …

I am very pleased and honoured to be asked to give this lecture in memory of Sir William
Bowman who as a clinician had considerable expertise in research techniques. After his …

Vascular endothelial growth factor (VEGF) is a critical stimulus for both retinal and choroidal
neovascularization, and for diabetic macular edema. We used mouse models for these …

Pigment epithelium-derived factor (PEDF) is a secreted glycoprotein and a non-inhibitory
member of the serine protease inhibitor (serpin) family. It is widely expressed in human fetal …

Diabetic retinopathy (DR), a chronic and progressive complication of diabetes mellitus, is a
sight-threatening disease characterized in the early stages by neuronal and vascular …