[HTML][HTML] Pigment epithelium-derived factor released by Müller glial cells exerts neuroprotective effects on retinal ganglion cells
JD Unterlauft, W Eichler, K Kuhne, XM Yang… - Neurochemical …, 2012 - Springer
Survival of retinal ganglion cells (RGC) is compromised in several vision-threatening
disorders such as ischemic and hypertensive retinopathies and glaucoma. Pigment …
disorders such as ischemic and hypertensive retinopathies and glaucoma. Pigment …
The many facets of PEDF in drug discovery and disease: a diamond in the rough or split personality disorder?
SE Craword, P Fitchev, D Veliceasa… - Expert opinion on drug …, 2013 - Taylor & Francis
Introduction: Pigment epithelium-derived factor (PEDF) was discovered as a neurotrophic
factor secreted by retinal pigment epithelial cells. A decade later, it re-emerged as a …
factor secreted by retinal pigment epithelial cells. A decade later, it re-emerged as a …
[HTML][HTML] Effects of human recombinant PEDF protein and PEDF-derived peptide 34-mer on choroidal neovascularization
J Amaral, SP Becerra - Investigative ophthalmology & visual …, 2010 - iovs.arvojournals.org
Purpose.: Pigment epithelium-derived factor (PEDF) is a serpin with antiangiogenic
properties. Previously, the authors showed that PEDF injected into the subconjunctiva …
properties. Previously, the authors showed that PEDF injected into the subconjunctiva …
Periocular injection of an adenoviral vector encoding pigment epithelium-derived factor inhibits choroidal neovascularization
P Gehlbach, AM Demetriades, S Yamamoto, T Deering… - Gene therapy, 2003 - nature.com
Gene transfer provides an exciting new approach for the treatment of retinal and choroidal
diseases. Two areas of concern are the potential for vector-related toxicity and uncertainties …
diseases. Two areas of concern are the potential for vector-related toxicity and uncertainties …
Retinal redox stress and remodeling in cardiometabolic syndrome and diabetes
Y Yang, MR Hayden, S Sowers… - Oxidative Medicine …, 2010 - Wiley Online Library
Diabetic retinopathy (DR) is a significant cause of global blindness; a major cause of
blindness in the United States in people aged between 20–74. There is emerging evidence …
blindness in the United States in people aged between 20–74. There is emerging evidence …
[HTML][HTML] Autophagy: a new mechanism for regulating VEGF and PEDF expression in retinal pigment epithelium cells
R Li, JH Du, GM Yao, Y Yao, J Zhang - International Journal of …, 2019 - ncbi.nlm.nih.gov
AIM To investigate the regulation of vascular endothelial growth factors (VEGF) and pigment
epithelium-derived factor (PEDF) expression by autophagy in retinal pigment epithelium …
epithelium-derived factor (PEDF) expression by autophagy in retinal pigment epithelium …
PEDF inhibits AGE-induced podocyte apoptosis via PPAR-gamma activation
Y Ishibashi, T Matsui, K Ohta, R Tanoue… - Microvascular …, 2013 - Elsevier
Advanced glycation end products (AGEs) formed at an accelerated rate under diabetes,
elicit oxidative and pro-apoptotic reactions in various types of cells, including podocytes …
elicit oxidative and pro-apoptotic reactions in various types of cells, including podocytes …
[HTML][HTML] PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy
S Gao, C Li, Y Zhu, Y Wang, A Sui, Y Zhong, B Xie… - Scientific reports, 2017 - nature.com
Macrophages have been demonstrated to play a proangiogenic role in retinal pathological
vascular growth. Pigment epithelium-derived factor (PEDF) works as a powerful …
vascular growth. Pigment epithelium-derived factor (PEDF) works as a powerful …
Pigment epithelium-derived factor inhibits advanced glycation end product-elicited mesangial cell damage by blocking NF-κB activation
Y Ide, T Matsui, Y Ishibashi, M Takeuchi… - Microvascular …, 2010 - Elsevier
Advanced glycation end products (AGE), senescent macroprotein derivatives formed at an
accelerated rate under hyperglycemic conditions, elicit oxidative stress generation and …
accelerated rate under hyperglycemic conditions, elicit oxidative stress generation and …
The role of gene therapy in the treatment of retinal diseases: a review
C Campa, CE Gallenga, E Bolletta… - Current Gene …, 2017 - ingentaconnect.com
Background: Gene therapy represents the therapeutic delivery of nucleic acid polymers into
patient cells with the aim of treating an underlying disease. Over the past 2 decades this new …
patient cells with the aim of treating an underlying disease. Over the past 2 decades this new …