Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …

Recent studies showed that germ‐free (GF) mice are resistant to obesity when consuming a
high‐fat, high‐carbohydrate Western diet. However, it remains unclear what mechanisms …

Atherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely
associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is …

Liver X receptors (LXRs) are ligand-activated transcription factors of the nuclear receptor
superfamily. There are two LXR isoforms termed α and ß which upon activation form …

Cholesterol is essential for the growth and function of all mammalian cells, but abnormally
increased blood cholesterol is a major risk factor for atherosclerotic cardiovascular disease …

Both alterations of lipid/lipoprotein metabolism and inflammatory events contribute to the
formation of the atherosclerotic plaque, characterized by the accumulation of abnormal …

Abstract Background Cardiovascular diseases (CVDs) are the leading cause of death
worldwide. Black pepper, the fruits of Piper nigrum L., is well known as “the king of spices” …

Along with many other mammalian ATP‐binding cassette (ABC) transporters, members of
the ABCG group are involved in the regulated transport of hydrophobic compounds across …

Rationale: The HDL (high-density lipoprotein)-mediated stimulation of cellular cholesterol
efflux initiates macrophage-specific reverse cholesterol transport (m-RCT), which ends in the …