Cholinergic modulation of glial function during aging and chronic neuroinflammation

R Gamage, I Wagnon, I Rossetti, R Childs… - Frontiers in Cellular …, 2020 - frontiersin.org
Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …

Contributions of DNA damage to Alzheimer's disease

X Lin, A Kapoor, Y Gu, MJ Chow, J Peng… - International journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common type of neurodegenerative disease. Its typical
pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau …

Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases

T Numakawa, R Kajihara - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in
neuronal differentiation, cell survival, and synaptic function in the peripheral and central …

Sex differences in stress response: classical mechanisms and beyond

GE Hodes, D Bangasser, I Sotiropoulos… - Current …, 2024 - benthamdirect.com
Neuropsychiatric disorders, which are associated with stress hormone dysregulation, occur
at different rates in men and women. Moreover, nowadays, preclinical and clinical evidence …

The complex relationship between obesity and neurodegenerative diseases: an updated review

A Neto, A Fernandes, A Barateiro - Frontiers in Cellular Neuroscience, 2023 - frontiersin.org
Obesity is a global epidemic, affecting roughly 30% of the world's population and predicted
to rise. This disease results from genetic, behavioral, societal, and environmental factors …

Interaction of Tau with the chemokine receptor, CX3CR1 and its effect on microglial activation, migration and proliferation

H Chidambaram, R Das, S Chinnathambi - Cell & bioscience, 2020 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease that leads to progressive loss of
memory and dementia. The pathological hallmarks of AD include extracellular accumulation …

Alzheimer's disease and specialized pro-resolving lipid mediators: Do MaR1, RvD1, and NPD1 show promise for prevention and treatment?

K Miyazawa, H Fukunaga, Y Tatewaki… - International Journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is a common neurodegenerative disease and a major contributor
to progressive cognitive impairment in an aging society. As the pathophysiology of AD …

Altered mitochondrial morphology and bioenergetics in a new yeast model expressing Aβ42

KK Epremyan, AG Rogov, TN Goleva… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is an incurable, age-related neurological disorder, the most
common form of dementia. Considering that AD is a multifactorial complex disease …

Alzheimer's disease: Significant benefit from the yeast-based models

KK Epremyan, DV Mamaev… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is an age-related, multifaceted neurological disorder associated
with accumulation of aggregated proteins (amyloid Aβ and hyperphosphorylated tau), loss of …

Sex-specific associations of serum cortisol with brain biomarkers of Alzheimer's risk

L Mosconi, S Williams, C Carlton, C Zarate, C Boneu… - Scientific Reports, 2024 - nature.com
Emerging evidence implicates chronic psychological stress as a risk factor for Alzheimer's
disease (AD). Herein, we examined the relationships between serum cortisol and …