Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans

JB Michel, JL Martin-Ventura, J Egido… - Cardiovascular …, 2011 - academic.oup.com
Aneurysm of the abdominal aorta (AAA) is a particular, specifically localized form of
atherothrombosis, providing a unique human model of this disease. The pathogenesis of …

Current status of medical management for abdominal aortic aneurysm

J Golledge, PE Norman - Atherosclerosis, 2011 - Elsevier
Previous trials indicate that surgical management of small abdominal aortic aneurysms
(AAA) does not reduce mortality. The medical management of AAA, however, has to a large …

[HTML][HTML] Challenges and opportunities in limiting abdominal aortic aneurysm growth

J Golledge, PE Norman, MP Murphy… - Journal of vascular …, 2017 - Elsevier
Objective This review describes ongoing efforts to develop a medical therapy to limit
abdominal aortic aneurysm (AAA) growth. Methods Data from animal model studies, human …

[HTML][HTML] Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms

W Eilenberg, B Zagrapan, S Bleichert, N Ibrahim… - Translational …, 2021 - Elsevier
Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of
abdominal aortic aneurysms (AAAs). This study has addressed the notion that NET …

[HTML][HTML] The abdominal aortic aneurysm and intraluminal thrombus: current concepts of development and treatment

A Piechota-Polanczyk, A Jozkowicz… - Frontiers in …, 2015 - frontiersin.org
The pathogenesis of the abdominal aortic aneurysm (AAA) shows several hallmarks of
atherosclerotic and atherothrombotic disease, but comprises an additional, predominant …

Mouse models for abdominal aortic aneurysm

J Golledge, SM Krishna, Y Wang - British Journal of …, 2022 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year.
Currently, the only treatment for AAA is surgical repair; however, this is only indicated for …

[HTML][HTML] Neutrophils as regulators and biomarkers of cardiovascular inflammation in the context of abdominal aortic aneurysms

J Klopf, C Brostjan, C Neumayer, W Eilenberg - Biomedicines, 2021 - mdpi.com
Neutrophils represent up to 70% of circulating leukocytes in healthy humans and combat
infection mostly by phagocytosis, degranulation and NETosis. It has been reported that …

Meta-analysis and meta-regression analysis of biomarkers for abdominal aortic aneurysm

PW Stather, DA Sidloff, N Dattani… - Journal of British …, 2014 - academic.oup.com
Background Many studies have investigated the systemic and local expression of
biomarkers in patients with abdominal aortic aneurysm (AAA). The natural history of AAA …

Surrogate markers of abdominal aortic aneurysm progression

A Wanhainen, K Mani, J Golledge - … , thrombosis, and vascular …, 2016 - Am Heart Assoc
The natural course of many abdominal aortic aneurysms (AAA) is to gradually expand and
eventually rupture and monitoring the disease progression is essential to their management …