Randomized placebo‐controlled trial assessing the effect of 24‐week fenofibrate therapy on circulating markers of abdominal aortic aneurysm: outcomes from the …
JL Pinchbeck, JV Moxon, SE Rowbotham… - Journal of the …, 2018 - Am Heart Assoc
Background There is no drug therapy for abdominal aortic aneurysm (AAA). FAME‐2
(Fenofibrate in the Management of Abdominal Aortic Aneurysm 2) was a placebo‐controlled …
(Fenofibrate in the Management of Abdominal Aortic Aneurysm 2) was a placebo‐controlled …
Systematic review of genome-wide association studies of abdominal aortic aneurysm
Background and aims Abdominal aortic aneurysm (AAA) is an important cause of death
worldwide and has an estimated heritability between 70 and 77%. Genome-wide …
worldwide and has an estimated heritability between 70 and 77%. Genome-wide …
[HTML][HTML] Parenteral administration of factor Xa/IIa inhibitors limits experimental aortic aneurysm and atherosclerosis
CS Moran, SW Seto, SM Krishna, S Sharma, RJ Jose… - Scientific reports, 2017 - nature.com
Intraluminal thrombus is a consistent feature of human abdominal aortic aneurysm (AAA).
Coagulation factor Xa (FXa) catalyses FII to thrombin (FIIa). We examined the effect of …
Coagulation factor Xa (FXa) catalyses FII to thrombin (FIIa). We examined the effect of …
Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target
TW Benson, MM Pike, A Spuzzillo, SM Hicks, S Ali… - Blood, 2024 - ashpublications.org
A common feature in patients with abdominal aortic aneurysms (AAAs) is the formation of a
nonocclusive intraluminal thrombus (ILT) in regions of aortic dilation. Platelets are known to …
nonocclusive intraluminal thrombus (ILT) in regions of aortic dilation. Platelets are known to …
Prognostic value of D-dimer and markers of coagulation for stratification of abdominal aortic aneurysm growth
AC Sundermann, K Saum, KA Conrad… - Blood …, 2018 - ashpublications.org
Abdominal aortic aneurysm (AAA) is associated with high morbidity and mortality and is an
established cause of unbalanced hemostasis. A number of hemostatic biomarkers have …
established cause of unbalanced hemostasis. A number of hemostatic biomarkers have …
[HTML][HTML] D-dimer is a diagnostic biomarker of abdominal aortic aneurysm in patients with peripheral artery disease
H Cai, B Pan, J Xu, S Liu, L Wang, K Wu… - Frontiers in …, 2022 - frontiersin.org
Background Etiology and risk factors of peripheral artery disease (PAD) include age,
smoking, and hypertension, etc., which are shared by an abdominal aortic aneurysm (AAA) …
smoking, and hypertension, etc., which are shared by an abdominal aortic aneurysm (AAA) …
Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm
E Bouwens, A Vanmaele, SE Hoeks… - Vascular …, 2023 - journals.sagepub.com
Background: Surveillance programs in abdominal aortic aneurysms (AAA) are mainly based
on imaging and leave room for improvement to timely identify patients at risk for AAA growth …
on imaging and leave room for improvement to timely identify patients at risk for AAA growth …
High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II …
SM Krishna, SW Seto, R Jose, J Li, J Moxon… - Clinical …, 2017 - portlandpress.com
Abdominal aortic aneurysm (AAA) is a common age-related vascular disease characterized
by progressive weakening and dilatation of the aortic wall. Thrombospondin-1 (TSP-1; gene …
by progressive weakening and dilatation of the aortic wall. Thrombospondin-1 (TSP-1; gene …
[HTML][HTML] Discovery of novel biomarkers for atherosclerotic aortic aneurysm through proteomics-based assessment of disease progression
H Yagi, M Nishigori, Y Murakami, T Osaki, S Muto… - Scientific reports, 2020 - nature.com
Since aortic aneurysms (AAs) are mostly asymptomatic, but they have a high mortality rate
upon rupture, their detection and progression evaluation are clinically important issues. To …
upon rupture, their detection and progression evaluation are clinically important issues. To …
Proteomic analysis of intra-arterial thrombus secretions reveals a negative association of clusterin and thrombospondin-1 with abdominal aortic aneurysm
OBJECTIVE: Abdominal aortic aneurysm (AAA) is usually accompanied by the formation of a
large volume of intra-luminal thrombus (ILT). ILT-derived proteins have been suggested as …
large volume of intra-luminal thrombus (ILT). ILT-derived proteins have been suggested as …