Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

Chronic unresolving inflammation is emerging as a key underlying pathological feature of
many if not most diseases ranging from autoimmune conditions to cardiometabolic and …

COVID‐19 is characterized by dysregulated immune responses, metabolic dysfunction and
adverse effects on the function of multiple organs. To understand host responses to COVID …

Sensing of pathogens by Toll-like receptor 4 (TLR4) induces an inflammatory response;
controlled responses confer immunity but uncontrolled responses cause harm. Here we …

The discovery of the transcription factor Forkhead box-p3 (Foxp3) has shed fundamental
insights into the understanding of the molecular determinants leading to generation and …

Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB), most human hosts are able to contain the infection and avoid progression to active TB …

Lidocaine is an amide-class local anesthetic used clinically to inhibit pain sensations.
Systemic administration of lidocaine has antinociceptive, antiarrhythmic, anti-inflammatory …

The therapeutic benefits of exogenously delivered mesenchymal stromal/stem cells (MSCs)
have been largely attributed to their secretory properties. However, clinical translation of …

Abstract Background Type 1, type 17, and other proinflammatory cytokines are important in
host immunity to tuberculosis (TB) in animal models. However, their role in human immunity …

Mesenchymal stem cell-derived exosomes have been under investigation as potential
treatments for a diverse range of diseases, and many animal and clinical trials have …