Integration of external control data, with patient-level information, in clinical trials has the
potential to accelerate the development of new treatments in neuro-oncology by …

It is not simple to consider the world from only one side, but analyzing all sides can cloud
comprehension without reaching deep insight found at the core. In a word as a whole, there …

Randomized control trials (RCTs) are required before drug and device approvals and have
contributed to patient safety, but they have also increased the cost and time of regulatory …

Stroke represents a major burden in patients with type 2 diabetes, yet this cerebrovascular
complication has been less carefully investigated than the risk of cardiovascular mortality …

Aim To describe baseline characteristics and follow‐up data in patients with lipodystrophy
syndromes treated with metreleptin in a national reference network, in a real‐life setting …

Background There have been ongoing efforts to understand when and how data from
observational studies can be applied to clinical and regulatory decision making. The …

Background Non-experimental studies (also known as observational studies) are valuable
for estimating the effects of various medical interventions, but are notoriously difficult to …

The CONVINCE trial demonstrates that high-dose hemodiafiltration offers a survival
advantage for patients in the high-flux hemodiafiltration group compared to hemodialysis …

Background Numerous observational studies have revealed an increased risk of death and
complications with transfusion, but this observation has not been confirmed in randomized …

Real‐world data are considered a potentially valuable source of evidence for assessing
medical technologies in clinical practice, but their widespread use is hampered by …