The incidence of obesity has dramatically increased over the last decades. Recently, there
has been a growing interest in the possible association between the pandemics of obesity …

The POUNDS Lost trial is a 2-year clinical trial testing the effects of dietary interventions on
weight loss. This study included 811 adults with overweight or obesity who were randomized …

Exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) is
associated with blood lipids in adults, but the underlying mechanisms remain unclear. This …

Context Carnitine palmitoyltransferase-1A, encoded by the CPT1A gene, plays a key role in
the oxidation of long-chain fatty acids in the mitochondria and may be important in …

The liver as the central organ is responsible for lipogenesis, gluconeogenesis and one-
carbon metabolism. Methyl donors (eg, betaine) modulate metabolic homeostasis and gene …

An earlier study of ours investigating the effect of dietary lipid levels on the choline
requirement of Atlantic salmon showed increasing severity of intestinal steatosis with …

Atherosclerosis is a significant risk factor for coronary heart disease (CHD) and myocardial
infarction (MI). Atherosclerosis develops during foam cell generation, which is caused by an …

The recent increase in obesity levels across many countries is likely to be driven by
nongenetic factors. The epigenetic modification DNA methylation (DNAm) may help to …

Background Observational studies have shown a causal association between dyslipidemia
and osteoporosis, but the genetic causation and complete mechanism of which are …

Background DNA-methylation has been associated with plasma lipid concentration in
populations of diverse ethnic backgrounds, but epigenome-wide association studies …