Mitochondrial Ca2+ and apoptosis

C Giorgi, F Baldassari, A Bononi, M Bonora… - Cell calcium, 2012 - Elsevier
Mitochondria are key decoding stations of the apoptotic process. In support of this view, a
large body of experimental evidence has unambiguously revealed that, in addition to the …

Vascular malformations: Part II: associated syndromes

MC Garzon, JT Huang, O Enjolras, IJ Frieden - Journal of the American …, 2007 - Elsevier
Cutaneous vascular malformations are rare disorders representing errors in vascular
development. These lesions occur much less commonly but are often confused with the …

A new model for brain tumor detection using ensemble transfer learning and quantum variational classifier

J Amin, MA Anjum, M Sharif, S Jabeen… - Computational …, 2022 - Wiley Online Library
A brain tumor is an abnormal enlargement of cells if not properly diagnosed. Early detection
of a brain tumor is critical for clinical practice and survival rates. Brain tumors arise in a …

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

RA Stockton, R Shenkar, IA Awad… - Journal of Experimental …, 2010 - rupress.org
Endothelial cell–cell junctions regulate vascular permeability, vasculogenesis, and
angiogenesis. Familial cerebral cavernous malformations (CCMs) in humans result from …

Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis

AL Akers, E Johnson, GK Steinberg… - Human molecular …, 2009 - academic.oup.com
Cerebral cavernous malformations (CCMs) are vascular anomalies of the central nervous
system, comprising dilated blood-filled capillaries lacking structural support. The lesions are …

Biology of vascular malformations of the brain

GG Leblanc, E Golanov, IA Awad, WL Young… - Stroke, 2009 - Am Heart Assoc
Background and Purpose—This review discusses recent research on the genetic,
molecular, cellular, and developmental mechanisms underlying the etiology of vascular …

Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation

CC Gibson, W Zhu, CT Davis, JA Bowman-Kirigin… - Circulation, 2015 - Am Heart Assoc
Background—Cerebral cavernous malformation (CCM) is a hemorrhagic stroke disease
affecting up to 0.5% of North Americans that has no approved nonsurgical treatment. A …

Hemorrhage from cavernous malformations of the brain: definition and reporting standards

R Al-Shahi Salman, MJ Berg, L Morrison, IA Awad - Stroke, 2008 - Am Heart Assoc
Background and Purpose—Cavernous malformations of the brain (CMs) cause intracranial
hemorrhage, but its reported frequency varies, partly attributable to study design. To improve …

Defective autophagy is a key feature of cerebral cavernous malformations

S Marchi, M Corricelli, E Trapani, L Bravi… - EMBO molecular …, 2015 - embopress.org
Cerebral cavernous malformation (CCM) is a major cerebrovascular disease affecting
approximately 0.3–0.5% of the population and is characterized by enlarged and leaky …

Cerebral cavernous malformations and epilepsy

I Awad, P Jabbour - Neurosurgical focus, 2006 - thejns.org
✓ Seizures and epilepsy are frequent clinical manifestations of cerebral cavernous
malformations (CCMs) and represent the most common symptomatic presentation of …