Type 2 diabetes

E Ahmad, S Lim, R Lamptey, DR Webb, MJ Davies - The Lancet, 2022 - thelancet.com
Type 2 diabetes accounts for nearly 90% of the approximately 537 million cases of diabetes
worldwide. The number affected is increasing rapidly with alarming trends in children and …

[HTML][HTML] Ten things to know about ten cardiovascular disease risk factors

HE Bays, PR Taub, E Epstein, ED Michos… - American journal of …, 2021 - Elsevier
Given rapid advancements in medical science, it is often challenging for the busy clinician to
remain up-to-date on the fundamental and multifaceted aspects of preventive cardiology and …

[HTML][HTML] Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments

SA Antar, NA Ashour, M Sharaky, M Khattab… - Biomedicine & …, 2023 - Elsevier
Nowadays, diabetes mellitus has emerged as a significant global public health concern with
a remarkable increase in its prevalence. This review article focuses on the definition of …

[HTML][HTML] A novel diabetes typology: towards precision diabetology from pathogenesis to treatment

C Herder, M Roden - Diabetologia, 2022 - Springer
The current classification of diabetes, based on hyperglycaemia, islet-directed antibodies
and some insufficiently defined clinical features, does not reflect differences in aetiological …

Personalized type 2 diabetes management: an update on recent advances and recommendations

DM Williams, H Jones, JW Stephens - … , Metabolic Syndrome and …, 2022 - Taylor & Francis
Previous guidelines for the treatment of people with type 2 diabetes mellitus (T2D) have
relied heavily upon rigid algorithms for the sequential addition of pharmacotherapies to …

[HTML][HTML] Phenotypic and genetic classification of diabetes

AJ Deutsch, E Ahlqvist, MS Udler - Diabetologia, 2022 - Springer
The historical subclassification of diabetes into predominantly types 1 and 2 is well
appreciated to inadequately capture the heterogeneity seen in patient presentations …

[HTML][HTML] Epigenetic dosage identifies two major and functionally distinct β cell subtypes

E Dror, L Fagnocchi, V Wegert, S Apostle, B Grimaldi… - Cell metabolism, 2023 - cell.com
The mechanisms that specify and stabilize cell subtypes remain poorly understood. Here,
we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (β …

[HTML][HTML] Ten things to know about ten cardiovascular disease risk factors–2022

HE Bays, A Agarwala, C German, P Satish… - American Journal of …, 2022 - Elsevier
ABSTRACT The American Society for Preventive Cardiology (ASPC)" Ten things to know
about ten cardiovascular disease risk factors–2022" is a summary document regarding …

Renoprotective mechanisms of sodium‐glucose co‐transporter 2 (SGLT2) inhibitors against the progression of diabetic kidney disease

S Ravindran, S Munusamy - Journal of cellular physiology, 2022 - Wiley Online Library
Sodium‐glucose co‐transporter 2 inhibitors (SGLT2‐Is) have emerged as a promising class
of antidiabetic drugs with cardioprotective and renoprotective effects in patients with type 2 …

[HTML][HTML] Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity

SA Nance, L Muir, C Lumeng - Molecular Metabolism, 2022 - Elsevier
Abstract Background Adipose tissue macrophages (ATMs) are a well characterized
regulator of adipose tissue inflammatory tone. Previously defined by the M1 vs M2 …