Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …

Chronic inflammation is believed to play crucial roles in the pathogenesis of various
diseases. Several types of drugs are used to treat inflammatory disorders, but they cause …

Natural products provide a vast array of chemical structures to explore in the discovery of
new medicines. Although secondary metabolites produced by microbes have been …

Revived analysis interests in natural products in the hope of discovering new and novel
antileishmanial drug leads have been driven partially by the increasing incidence of drug …

Natural products, or secondary metabolites, obtained from fungal species associated with
marine algae have been widely used in sunscreens due to their antioxidant activity and …

Antibiotic resistance genes are found in a broad range of ecological niches associated with
complex microbiota. Here we investigated if resistance genes are not only present, but also …

Marine organisms comprising microbes, plants, invertebrates, and vertebrates elaborate an
impressive array of structurally diverse antimicrobial products ranging from small cyclic …

Lajollamycins (1–4), each of which bears a spiro-β-lactone-γ-lactam ring and a nitro-
tetraene moiety, were obtained from a marine-derived Streptomyces strain isolated from the …

In Brazil, deep-sea marine environments extend over 3.5 million km 2, covering nearly 80%
of Brazil's Economic Exclusive Zone (EEZ) in the southern tropical and subtropical Atlantic …

The first total synthesis of lajollamycin B, a structurally novel nitro‐tetraene spiro‐β‐lactone/γ‐
lactone antibiotic, is described. The convergent synthesis involves the construction of the …