Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …

Prostate cancer is considered a disease of older men (aged> 65 years), but today over 10%
of new diagnoses in the USA occur in young men aged≤ 55 years. Early-onset prostate …

Background BRCA1 and BRCA2 mutations have been associated with prostate cancer
(PCa) risk but a wide range of risk estimates have been reported that are based on …

Background Prostate cancer is a significant public health issue in the United States. It is the
most commonly diagnosed non-skin cancer and the second leading cause of cancer death …

Abstract Objectives The Swedish Family-Cancer Database has been the major source of
population-based prospective data on familial risks on most cancers, including prostate …

Studies on familial aggregation of cancer may suggest an overall contribution of inherited
genes or a shared environment in the development of malignant disease. We performed a …

BACKGROUND Prostate cancer (PC) relative risks (RRs) are typically estimated based on
status of close relatives or presence of any affected relatives. This study provides RR …

Background The risk of high-grade prostate cancer, given a family history of cancer, has
been described in the general population, but not among men selected for prostate biopsy in …

CONTEXT: Widespread mass screening of prostate cancer (PCa) is not recommended
because the balance between benefits and harms is still not well established. The achieved …

Simple Summary Familial cancer can be defined through the occurrence of the same cancer
in two or more family members. Hereditary cancer is a narrower definition of high-risk …