Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …

The importance of EZH2 as a key methyltransferase has been well documented
theoretically. Practically, the first EZH2 inhibitor Tazemetostat (EPZ6438), was approved by …

In the recent past, proteolysis-targeting chimera (PROTAC) technology has received
enormous attention for its ability to overcome the limitations of protein inhibitors and its …

The past decades have seen tremendous developments with respect to “specific”
therapeutics that target key signaling molecules to conquer cancer. The key advancements …

Histone lysine methylation is a post-translational modification that plays a key role in the
epigenetic regulation of a broad spectrum of biological processes. Moreover, the …

As negative modulators of G-protein-coupled receptors (GPCRs) signaling, regulators of G
protein signaling (RGS) proteins facilitate various downstream cellular signalings through …

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with
insufficient options for therapy. In order to identify new targets and treatment modalities we …

Influenza is an acute respiratory infection caused by influenza viruses (IFV), According to the
World Health Organization (WHO), seasonal IFV epidemics result in approximately 3–5 …

Female breast cancer has become the most commonly occurring cancer worldwide.
Although it has a good prognosis under early diagnosis and appropriate treatment, breast …

Esophageal squamous cell carcinoma is a type of cancer with dismal prognosis. Surgery,
chemo-and radiation therapy, as well as immune checkpoint-blocking immunotherapy lead …