Innovations in genomics and big data analytics for personalized medicine and health care: A review
Big data in health care is a fast-growing field and a new paradigm that is transforming case-
based studies to large-scale, data-driven research. As big data is dependent on the …
based studies to large-scale, data-driven research. As big data is dependent on the …
[HTML][HTML] DNA methylation in the pathogenesis of type 2 diabetes in humans
Abstract Background Type 2 diabetes (T2D) is a multifactorial, polygenic disease caused by
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …
Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
Host genetics are known to influence the gut microbiome, yet their role remains poorly
understood. To robustly characterize these effects, we performed a genome-wide …
understood. To robustly characterize these effects, we performed a genome-wide …
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
[HTML][HTML] The transcriptional landscape of age in human peripheral blood
MJ Peters, R Joehanes, LC Pilling… - Nature …, 2015 - nature.com
Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …
to increased disease susceptibility remain inadequately understood. Here we perform a …
Disease variants alter transcription factor levels and methylation of their binding sites
Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences,. Identification of expression …
experiments to understand their functional consequences,. Identification of expression …
Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
L Barbier-Torres, KA Fortner, P Iruzubieta… - Nature …, 2020 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is considered the next major health epidemic with
an estimated 25% worldwide prevalence. No drugs have yet been approved and NAFLD …
an estimated 25% worldwide prevalence. No drugs have yet been approved and NAFLD …
Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation
LT Husquin, M Rotival, M Fagny, H Quach, N Zidane… - Genome biology, 2018 - Springer
Background DNA methylation is influenced by both environmental and genetic factors and is
increasingly thought to affect variation in complex traits and diseases. Yet, the extent of …
increasingly thought to affect variation in complex traits and diseases. Yet, the extent of …
Genotype harmonizer: automatic strand alignment and format conversion for genotype data integration
Background To gain statistical power or to allow fine mapping, researchers typically want to
pool data before meta-analyses or genotype imputation. However, the necessary …
pool data before meta-analyses or genotype imputation. However, the necessary …
Human ontogeny of drug transporters: review and recommendations of the pediatric transporter working group
KLR Brouwer, LM Aleksunes, B Brandys… - Clinical …, 2015 - Wiley Online Library
The critical importance of membrane‐bound transporters in pharmacotherapy is widely
recognized, but little is known about drug transporter activity in children. In this white paper …
recognized, but little is known about drug transporter activity in children. In this white paper …