Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …

Glaucoma is a leading cause of irreversible blindness worldwide. Elevated intraocular
pressure (IOP) is considered to be a predominant risk factor for primary open angle …

Background Adipose derived stem cells can be stimulated to produce a growth factor rich
secretome which enhances axon regeneration. In this study we investigated the importance …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, yet
disease-modifying treatments do not currently exist. Rho-associated protein kinase (ROCK) …

Central nervous system (CNS) injury, including stroke, spinal cord injury, and traumatic brain
injury, causes severe neurological symptoms such as sensory and motor deficits. Currently …

Neurons depend on mitochondrial functions for membrane excitability, neurotransmission,
and plasticity. Mitochondrial dynamics are important for neural cell maintenance. To …

Synaptic spine morphology is controlled by the activity of Rac1, Cdc42 and RhoA, which
need to be finely balanced, and in particular RhoA/ROCK prevents the formation of new …

Intraocular pressure (IOP)-lowering ophthalmic solutions that inhibit Rho-associated protein
kinases (Rock) and norepinephrine transporters (Net) are currently under clinical evaluation …

ROCK inhibition has been largely applied as a strategy to treat neurodegenerative diseases
(NDDs) and promising results have been obtained in the recent years. However, the …

The aim of the present study was to determine whether adeno-associated viral vector (AAV)
mediated transfer of ciliary neurotrophic factor (CNTF) and RhoA shRNA has additive effects …