The discovery of telomeres dates back to the early 20th century. In humans, telomeres are
heterochromatic structures with tandem DNA repeats of 5′‐TTAGGG‐3′ at the …

Telomerase is the enzyme responsible for maintenance of the length of telomeres by
addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes …

Patients with dyskeratosis congenita (DC), a disorder of telomere maintenance, suffer
degeneration of multiple tissues,,. Patient-specific induced pluripotent stem (iPS) cells …

Human telomerase reverse transcriptase (hTERT; the catalytic protein subunit of
telomerase) is subjected to numerous alternative splicing events, but the regulation and …

Telomeres are crucial in the maintenance of chromosome integrity and genomic stability. A
series of epidemiological studies have examined the association between telomere length …

Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …

Regulator of telomere elongation 1 (RTEL1) is known as a DNA helicase that is important for
telomeres and genome integrity. However, the diverse phenotypes of RTEL1 dysfunction …

Telomeres are specialised structures at the end of linear chromosomes. They consist of
tandem repeats of the hexanucleotide sequence TTAGGG, as well as a protein complex …

Telomerase is a ribonucleoprotein enzyme complex that adds telomeric repeats to the ends
of chromosomes. The core telomerase components are the telomerase reverse transcriptase …

One of the hallmarks of advanced malignancies is continuous cell growth and this almost
universally correlates with the reactivation of telomerase. Although there is still much we do …