Sequencing of all human immunoglobulin (Ig) germline gene segments has recently been
completed. However, our first glimpses of the recombined products of this combinatorial …

There is a need for protein‐specific affinity reagents to explore the gene products encoded
by the genome. Recently, systematic efforts to generate validated affinity reagents on a …

Novel multispecific antigen-binding molecules maintaining excellent cellular cytotoxicity and
high stability, which comprise a domain that contains an antibody variable region having …

An important concern for the use of antibodies in various applications, such as western blot
(WB) or immunohistochemistry (IHC), is specificity. This calls for systematic validations using …

Use of phage display of recombinant antibodies and large repertoire naı̈ve antibody
libraries for identifying antibodies of high specificity has been extensively reported …

Antibodies have profound relevance as research tools and in diagnostic and therapeutic
applications. However, the identification of useful antibodies is difficult and once identified …

The growing field of biotechnology is in constant need of binding proteins with novel
properties. Not just binding specificities and affinities but also structural stability and …

Many factors influence the choice of methods used to develop antibody to infectious agents.
In this paper, we review the current status of the main technologies used to produce …

Figure 1. An approach for constructing scFv fragments that display germline CDR
combinations not accessible to nature. cDNA is produced from immunoglobulin-secreting …

Antibodies have profound relevance as research tools and in diagnostic and therapeutic
applications. However, the identification of useful antibodies is difficult and once identified …