Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia
but it is not clear if this dysregulation is detectable in both brain and blood. We examined …

Objective: The mechanisms leading to schizophrenia are likely to be diverse. However,
there may be common pathophysiological pathways for subtypes of the disease. The …

Metabotropic glutamate receptor subtype 5 (mGluR5), encoded by the GRM5 gene,
represents a compelling novel drug target for the treatment of schizophrenia. mGluR5 is a …

Ufmylation is a type of post-translational modification that deals with complex and fine-tuned
cellular activities. This modification proceeds mainly through a three-step enzymatic reaction …

Alcoholic steatohepatitis (ASH) is a progression hepatitis with severe fatty liver and its
mortality rate for 30-days in patients are over 30%. Additionally, ASH is well known for one …

Ufmylation is implicated in multiple cellular processes, but little is known about its functions
and regulation in protein trafficking. Here, we demonstrate that the genetic depletion of core …

Schizophrenia is a chronic disease characterized by the impairment of mental functions with
a marked social dysfunction. A quantitative proteomic approach using iTRAQ labeling and …

Schizophrenia is a chronic, severe and disabling psychiatric disorder, whose treatment is
based on psychosocial interventions and the use of antipsychotic drugs. While the effects of …

Schizophrenia is a common psychiatric disorder with high heritability and complex genetic
architecture. Genome-wide association studies (GWAS) have identified several significant …

Abstract Ubiquitin‐fold modifier 1 (UFM1) is a reversible post‐translational modifier that is
covalently attached to target proteins through an enzymatic cascade and removed by …