It is not yet established whether oxidative stress is a major cause of cell death or simply a
consequence of an unknown pathogenetic factor. Concerning chronic diseases, as …

The expression of phase-II detoxification and antioxidant enzymes is governed by a cis-
acting regulatory element named the antioxidant response element (ARE). ARE-containing …

The tripeptide glutathione (GSH) has been thoroughly investigated in relation to its role as
antioxidant and free radical scavenger. In recent years, novel actions of GSH in the nervous …

The characteristics and kinetics of GSH efflux from the monolayer culture of rat astrocytes
were investigated. GSH efflux was dependent on temperature, with a Q10 value of 2.0 …

Based on the concept of the tripartite synapse, we have reviewed the role of glucose-derived
compounds in glycolytic pathways in astroglial cells. Glucose provides energy and substrate …

A study was made of the effects of reduced (GSH) and oxidized (GSSG) glutathione on the
Na+-independent and N-methyl-D-aspartate (NMDA) displaceable bindings of glutamate, on …

Cellular redox status is an important factor during neuronal apoptosis. In primary cultures of
chick embryonic neurons, serum deprivation and treatment with staurosporine (200 nM) for …

The physiological significance of glutathione in the mammalian central nervous system is
still uncertain, although some evidence indicates that it may be an important regulatory …

Introduction General Biological Properties of Glutathione Concentration of Sulfur-Containing
Amino Acids in Vivo Subcellular Localization of Glutathione in the Brain Cellular …

Gamma glutamyl cysteine ligase (GCL) is the rate-limiting enzyme for intracellular
glutathione (GSH) synthesis. The GSH concentration and GCL activity are declining with age …