Multidrug resistance (MDR) is a serious phenomenon employed by cancer cells which
hampers the success of cancer pharmacotherapy. One of the common mechanisms of MDR …

Abstract P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1
gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …

Oral bioavailability measurements in rats for over 1100 drug candidates studied at
SmithKline Beecham Pharmaceuticals (now GlaxoSmithKline) have allowed us to analyze …

One of the major causes of failure in cancer chemotherapy is multidrug resistance (MDR),
where cancer cells simultaneously become resistant to different anticancer drugs. Over …

Over the past 15 years the privileged structure concept has emerged as a fruitful approach to
the discovery of novel biologically active molecules. Privileged structures are molecular …

Splenda is comprised of the high-potency artificial sweetener sucralose (1.1%) and the
fillers maltodextrin and glucose. Splenda was administered by oral gavage at 100, 300, 500 …

Targeted therapy has been a very promising strategy of drug development research. Many
molecular mechanims of diseases have been known to be regulated by abundance of …

Relative plasma, brain and cerebrospinal fluid (CSF) exposures and unbound fractions in
plasma and brain were examined for 18 proprietary compounds in rats. The relationship …

Sucralose is a synthetic organochlorine sweetener (OC) that is a common ingredient in the
world's food supply. Sucralose interacts with chemosensors in the alimentary tract that play a …

The opioids are commonly used to treat acute and severe pain. Long-term opioid
administration eventually reaches a dose ceiling that is attributable to the rapid onset of …