Cholesterol accumulation on dendritic cells reverses chronic hepatitis B virus infection-induced dysfunction

H Zhao, Y Yu, Y Wang, L Zhao, A Yang, Y Hu… - Cellular & Molecular …, 2022 - nature.com
Chronic hepatitis B (CHB) infection remains a serious public health problem worldwide;
however, the relationship between cholesterol levels and CHB remains unclear. We isolated …

Hepatitis B Therapeutic Vaccine: A Patent Review

SA Hudu, AO Jimoh, KG Ibrahim, AS Alshrari - Pharmaceuticals, 2022 - mdpi.com
Viral hepatitis has long been underrated as a danger to global health. The UN only recently
called for worldwide action to tackle viral hepatitis and lessen the disease burden in its …

An angel or a devil? Current view on the role of CD8+ T cells in the pathogenesis of myasthenia gravis

Y Peng, H Yang, Q Chen, H Jin, Y Xue, M Du… - Journal of Translational …, 2024 - Springer
Background Myasthenia gravis (MG) and the experimental autoimmune MG (EAMG) animal
model are characterized by T-cell-induced and B-cell-dominated autoimmune diseases that …

Intranasal immunization with HRSV prefusion F protein and CpG adjuvant elicits robust protective effects in mice

H Ren, H Li, L Cao, Z Wang, Y Zhou, J Guo, Y Zhang… - Vaccine, 2022 - Elsevier
Human respiratory syncytial virus (HRSV) is a leading cause of lower respiratory tract
infections in elderly individuals and young children/infants and can cause bronchiolitis and …

Ferrocene-conjugated polymeric platform via amide bond formation facilitates enhanced in situ fenton reaction and robust immune responses in combination with toll …

Y Hao, H Li, F Ren, R Feng, Y Liu, X Li, H Chen… - Chemical Engineering …, 2023 - Elsevier
Chemodynamic therapy (CDT) holds promise for catalyzing in situ Fenton/Fenton-like
reactions by decomposing H 2 O 2 to produce highly toxic hydroxyl radicals (• OH). As a …

Advances in Vaccine Adjuvants: Nanomaterials and Small Molecules

B Sun, M Li, Z Yao, G Yu, Y Ma - 2023 - Springer
Adjuvants have been extensively and essentially formulated in subunits and certain
inactivated vaccines for enhancing and prolonging protective immunity against infections …

Optimized cationic lipid-assisted nanoparticle for delivering CpG oligodeoxynucleotides to treat Hepatitis B virus infection

YF Chen, Y Wang, Y Wang, YL Luo, ZD Lu… - Pharmaceutical …, 2023 - Springer
Abstract Purpose Hepatitis B virus (HBV) infection is such a global health problem that
hundreds of millions of people are HBV carriers. Current anti-viral agents can inhibit HBV …

Role of CXCR5+ CD8+ T cells in human hepatitis B virus infection

J Zhou, X He, Y Ou, S Peng, D Li, Q Zhou… - Journal of Viral …, 2023 - Wiley Online Library
The replication of HBV in hepatocytes can be effectively inhibited by lifelong antiviral
therapy. Because of the long‐term presence of HBV reservoirs, the virus rebound frequently …

[HTML][HTML] AdjuvareDB: A comprehensive database for candidate adjuvant compendium in clinic

D Ren, J Jin, S Xiong, D Xia, X Zhao… - Clinical and …, 2024 - ncbi.nlm.nih.gov
Dear Editor, Adjuvants are important components of vaccination, stimulating and enhancing
the strength and duration of immune responses. 1 To provide a comprehensive …