Terpenoids are the largest class of natural products, most of which are derived from plants.
Amongst their numerous biological properties, their anti-tumor effects are of interest for they …

Inflammation is an integral part of autoimmune diseases, which are caused by dysregulation
of the immune system. This dysregulation involves an imbalance between pro-inflammatory …

Background Although cisplatin-based chemotherapy has been used as the first-line
treatment for ovarian cancer (OC), tumor cells develop resistance to cisplatin during …

Triptolide exhibits promising efficacy in various cancers and immune diseases while its
clinical application has been strongly restricted by its severe side effects, especially …

Diabetic nephropathy (DN), a sterile inflammatory disease, is a serious complication of
diabetes mellitus. However, recent evidence indicates that pyroptosis, a new term for pro …

In photodynamic therapy (PDT), elevated reactive oxygen species (ROS) activate tumor cell
protective autophagy, therefore attenuating the antitumor function of therapy. Hence …

Covalent chemistry coupled with activity-based protein profiling (ABPP) offers a versatile
way to discover ligands for proteins in native biological systems. Here, we describe a set of …

Background and Purpose Triptolide (TP) elicits a beneficial effect in the treatment of
autoimmune diseases, such as ulcerative colitis (UC) and rheumatoid arthritis (RA) …

Gangliosides are a large subfamily of glycosphingolipids that broadly exist in the nervous
system and interact with signaling molecules in the lipid rafts. GD3 and GD2 are two types of …

Chronic inflammation is a common underlying factor in many major diseases, including
heart disease, diabetes, cancer, and autoimmune disorders, and is responsible for up to …