Discerning molecular interactions: a comprehensive review on biomolecular interaction databases and network analysis tools

SK Miryala, A Anbarasu, S Ramaiah - Gene, 2018 - Elsevier
Computational analysis of biomolecular interaction networks is now gaining a lot of
importance to understand the functions of novel genes/proteins. Gene interaction (GI) …

Gene interaction network studies to decipher the multi-drug resistance mechanism in Salmonella enterica serovar Typhi CT18 reveal potential drug targets

R Debroy, SK Miryala, A Naha, A Anbarasu… - Microbial …, 2020 - Elsevier
Salmonella enterica subsp. enterica serovar Typhi, a human enteric pathogen causing
typhoid fever, developed resistance to multiple antibiotics over the years. The current study …

[HTML][HTML] Resistance elicited by sub-lethal concentrations of ampicillin is partially mediated by quorum sensing in Pseudomonas aeruginosa

Y Li, L Xia, J Chen, Y Lian, AA Dandekar, F Xu… - Environment …, 2021 - Elsevier
The rapid increase of antibiotic resistance is a serious challenge around the world.
Antibiotics are present in various environments at sub-lethal concentrations, but how …

Gene interaction network approach to elucidate the multidrug resistance mechanisms in the pathogenic bacterial strain Proteus mirabilis

SK Miryala, A Anbarasu… - Journal of Cellular …, 2021 - Wiley Online Library
Proteus mirabilis is one among the most frequently identified pathogen in patients with the
urinary tract infection. The multidrug resistance exhibited by P. mirabilis renders the …

Amalgamation of 3d structure and sequence information for protein–protein interaction prediction

K Jha, S Saha - Scientific Reports, 2020 - nature.com
Protein is the primary building block of living organisms. It interacts with other proteins and is
then involved in various biological processes. Protein–protein interactions (PPIs) help in …

Systems biology studies in Pseudomonas aeruginosa PA01 to understand their role in biofilm formation and multidrug efflux pumps

SK Miryala, A Anbarasu, S Ramaiah - Microbial pathogenesis, 2019 - Elsevier
The antimicrobial resistance (AMR) exhibited against broad spectrum and new generation
antibiotics used for Pseudomonas infections is a major threat and renders the treatment …

Impact of bedaquiline and capreomycin on the gene expression patterns of multidrug‐resistant Mycobacterium tuberculosis H37Rv strain and understanding the …

SK Miryala, A Anbarasu… - Journal of Cellular …, 2019 - Wiley Online Library
The emergence of multidrug resistance (MDR), extensively drug‐resistant, and total drug‐
resistant Mycobacterium tuberculosis (Mtb) strains have hampered the treatment of …

Natural Inhibitors of HMG‐CoA Reductase—An Insilico Approach Through Molecular Docking and Simulation Studies

S Suganya, B Nandagopal… - Journal of cellular …, 2017 - Wiley Online Library
Plant products have always been considered for many important metabolic disorders due to
its abundant medicinal properties. Alarming adverse effects of overuse of statins has been …

Role of SHV-11, a Class A β-Lactamase, Gene in Multidrug Resistance Among Klebsiella pneumoniae Strains and Understanding Its Mechanism by Gene Network …

SK Miryala, A Anbarasu, S Ramaiah - Microbial Drug Resistance, 2020 - liebertpub.com
Aim: The rapid emergence of β-lactam resistance in gram-negative bacteria is a major
problem in the treatment of infections caused by pathogenic bacterial strains, in particular …

MurB as a target in an alternative approach to tackle the Vibrio cholerae resistance using molecular docking and simulation study

A Ragunathan, K Malathi… - Journal of Cellular …, 2018 - Wiley Online Library
Cholera is a serious threat to a large population in the under developed countries. Though
oral rehydration therapy is the preferred choice of treatment, the use of antibiotics could …