Obesity has become a major epidemic in the 21st century. It increases the risk of
dyslipidemia, hypertension, and type 2 diabetes, which are known cardiometabolic risk …

This contemporary, international, evidence-informed guidance aims to achieve the greatest
good for the greatest number of people with familial hypercholesterolaemia (FH) across …

The current and long-term health of 14.4 million children and adolescents is affected by
obesity, 1, 2 making it one of the most common pediatric chronic diseases. 3–5 Long …

Background Childhood cardiovascular risk factors predict subclinical adult cardiovascular
disease, but links to clinical events are unclear. Methods In a prospective cohort study …

The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …

There is a need to identify high-risk features that predict early-onset atherosclerotic
cardiovascular disease (ASCVD). The authors provide insights to help clinicians identify and …

Chronic kidney disease (CKD) affects many adults worldwide. Persistent low-grade
inflammation is a substantial factor in its development and progression and has correlated …

Lipid disorders involving derangements in serum cholesterol, triglycerides, or both are
commonly encountered in clinical practice and often have implications for cardiovascular …

Definition and management of arterial hypertension in children and adolescents are
uncertain, due to different positions of current guidelines. The European Society of …

Níveis de evidência Nível A Dados obtidos a partir de múltiplos estudos randomizados de
bom porte, concordantes e/ou de meta-análise robusta de estudos clínicos randomizados …