Highlights•Legionella pneumophila has the largest known bacterial arsenal of effector
proteins (330+).•Extensive functional redundancy exists between effectors and may result …

Type-IV secretion systems are devices present in a wide range of bacteria (including
bacterial pathogens) that deliver macromolecules (proteins and single-strand-DNA) across …

Legionella pneumophila replicates inside alveolar macrophages and causes an acute,
potentially fatal pneumonia called Legionnaires' disease. The ability of this bacterium to …

Type II protein secretion is critical for Legionella pneumophila infection of amoebae,
macrophages, and mice. Previously, we found several enzymes to be secreted by this (Lsp) …

Legionella pneumophila requires the Dot/Icm protein translocation system to replicate within
host cells as a critical component of Legionnaire's pneumonia. None of the known individual …

Amoebae-resistant microorganisms exhibit a specific lifestyle. Unlike allopatric specialized
intracellular pathogens, they have not specialized because they infect the amoebae via …

Legionella pneumophila, the causative agent of Legionnaires' disease, uses the intracellular
multiplication/defective organelle trafficking (Icm/Dot) type IV secretion system to establish …

Legionella pneumophila invades and replicates intracellularly in human and protozoan
hosts. The bacteria use the Icm/Dot type IVB secretion system to translocate effectors that …

Type IV secretion systems (T4SSs) play a central role in the pathogenicity of many important
pathogens, including Agrobacterium tumefaciens, Helicobacter pylori, and Legionella …

Abstract Background The genus Legionella comprises over 60 species. However, L.
pneumophila and L. longbeachae alone cause over 95% of Legionnaires' disease. To …