Adaptation of Legionella pneumophila to the host environment: role of protein secretion, effectors and eukaryotic-like proteins

H Brüggemann, C Cazalet, C Buchrieser - Current opinion in microbiology, 2006 - Elsevier
The intracellular pathogen Legionella pneumophila has evolved sophisticated mechanisms
that enable it to subvert host functions, enter, survive and replicate in amoebae or alveolar …

A Dot/Icm‐translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa

S Al‐Khodor, CT Price, F Habyarimana… - Molecular …, 2008 - Wiley Online Library
Summary The Dot/Icm type IV secretion system of Legionella pneumophila translocates
numerous bacterial effectors into the host cell and is essential for bacterial proliferation …

Quantitative Real-Time Legionella PCR for Environmental Water Samples: Data Interpretation

P Joly, PA Falconnet, J André, N Weill… - Applied and …, 2006 - Am Soc Microbiol
ABSTRACT Quantitative Legionella PCRs targeting the 16S rRNA gene (specific for the
genus Legionella) and the mip gene (specific for the species Legionella pneumophila) were …

Legionella pneumophila

IG Gonçalves, LC Simões, ML Simões - 2021 - repositorium.sdum.uminho.pt
Legionella pneumophila is an intracellular pathogen, ubiquitous in the environment and
considered opportunistic. It is the leading cause of legionellosis, which can be present in its …

Molecular epidemiology, phylogeny and evolution of Legionella

A Khodr, E Kay, L Gomez-Valero, C Ginevra… - Infection, genetics and …, 2016 - Elsevier
Legionella are opportunistic pathogens that develop in aquatic environments where they
multiply in protozoa. When infected aerosols reach the human respiratory tract they may …

A pilot study of rapid whole-genome sequencing for the investigation of a Legionella outbreak

S Reuter, TG Harrison, CU Köser, MJ Ellington… - BMJ open, 2013 - bmjopen.bmj.com
Objectives Epidemiological investigations of Legionnaires' disease outbreaks rely on the
rapid identification and typing of clinical and environmental Legionella isolates in order to …

[HTML][HTML] Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systems

A Angot, A Vergunst, S Genin, N Peeters - PLoS pathogens, 2007 - journals.plos.org
The specific and covalent addition of ubiquitin to proteins, known as ubiquitination, is a
eukaryotic-specific modification central to many cellular processes, such as cell cycle …

Legionella pneumophila Dot/Icm translocated substrates: a sum of parts

AW Ensminger, RR Isberg - Current opinion in microbiology, 2009 - Elsevier
Legionella pneumophila is an intracellular pathogen of freshwater amoeba and of alveolar
macrophages in human hosts. After phagocytosis, L. pneumophila establishes a unique …

[HTML][HTML] Type IV Secretion-Dependent Activation of Host MAP Kinases Induces an Increased Proinflammatory Cytokine Response to Legionella pneumophila

S Shin, CL Case, KA Archer, CV Nogueira… - PLoS …, 2008 - journals.plos.org
The immune system must discriminate between pathogenic and nonpathogenic microbes in
order to initiate an appropriate response. Toll-like receptors (TLRs) detect microbial …

Temperature-Regulated Formation of Mycelial Mat-Like Biofilms by Legionella pneumophila

Z Piao, CC Sze, O Barysheva, K Iida… - Applied and …, 2006 - Am Soc Microbiol
Fifty strains representing 38 species of the genus Legionella were examined for biofilm
formation on glass, polystyrene, and polypropylene surfaces in static cultures at 25° C, 37° …