Microbial communities in the lungs of patients with cystic fibrosis (CF) and chronic
obstructive pulmonary disease (COPD) have been shown to be spatially heterogeneous …

Within the human host, Legionella pneumophila replicates within alveolar macrophages,
leading to pneumonia. However, L. pneumophila is an aquatic generalist pathogen that …

Horizontal gene transfer probably contributes to evolution of Legionella pneumophila and its
adaptation to different environments. Although horizontal gene transfer was observed in …

Legionella pneumophila (Lp) is commonly found in freshwater habitats but is also the
causative agent of Legionnaires' disease when infecting humans. Although various …

In aquatic environments, biofilms constitute an ecological niche where Legionella
pneumophila persists as sessile cells. However, very little information on the sessile mode of …

A first strong evidence of person-to-person transmission of Legionnaires' Disease (LD) was
recently reported. Here, we characterize the genetic backbone of this case-related …

Sažetak ATP-sensitive potassium (KATP) channels are a major drug target for the treatment
of type-2 diabetes. KATP channels are ubiquitously expressed and link the metabolic state …

Legionella pneumophila, the causative agent of Legionnaires' disease, is known to be an
intracellular pathogen of multiple species of protozoa and is assumed to have co-evolved …

Iron is essential for the growth and virulence of most intravacuolar pathogens. The
mechanisms by which microbes bypass host iron restriction to gain access to this metal …

The intracellular pathogen Legionella pneumophila encodes translocated effector proteins
that modify host cell processes to support bacterial survival and growth. Here, we show that …