With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

Ageing and diabetes lead to similar organ dysfunction that is driven by parallel molecular
mechanisms, one of which is cellular senescence. The abundance of senescent cells in …

Malignant tumors exhibit heterogeneous metabolic reprogramming, hindering the
identification of translatable vulnerabilities for metabolism-targeted therapy. How molecular …

Gallbladder cancer (GBC) is rare, but is the most malignant type of biliary tract tumor.
Unfortunately, only a small population of cancer patients is acceptable for the surgical …

In this review, we summarize current knowledge on the genetics of coronary artery disease,
based on 10 years of genome-wide association studies. The discoveries began with …

It is widely accepted that senescent cells accumulate with aging. They are characterized by
replicative arrest and the release of a myriad of factors commonly called the senescence …

The CDKN2A/B genomic locus is associated with risk of human cancers and metabolic
disease. Although the locus contains several important protein-coding genes, studies …

Inappropriate expansion of the adipose cells in the subcutaneous adipose tissue (SAT) is a
characteristic of hypertrophic obesity and of individuals with genetic predisposition for T2D …

Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and
environmental risk factors. Together, 6 previously identified risk loci only explain a small …

Metabolic disorders are increasingly prevalent worldwide, leading to high rates of morbidity
and mortality. The variety of metabolic illnesses can be addressed through personalized …