Non-antibiotic drug repositioning as an alternative antimicrobial approach

A Barbarossa, A Rosato, F Corbo, ML Clodoveo… - Antibiotics, 2022 - mdpi.com
The worldwide scenario of antibiotic resistance and the falling number of funds for the
development of novel antibiotics have led research efforts toward the study of specific cost …

Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment

SM Sousa, CPR Xavier… - Current Topics in …, 2023 - ingentaconnect.com
Drug repurposing is a strategy used to develop new treatments based on approved or
investigational drugs outside the scope of their original clinical indication. Since this …

Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models

MI Han, P Atalay, CÜ Tunç, G Ünal, S Dayan… - Bioorganic & Medicinal …, 2021 - Elsevier
Naproxen is a common non-steroidal anti-inflammatory drug, which is the most usually used
propionic acid derivative for the treatment of many types of diseases. In this study, a series of …

Synthesis and investigation of anti-inflammatory activity of new thiourea derivatives of naproxen

N Nedeljković, V Dobričić, J Bošković, M Vesović… - Pharmaceuticals, 2023 - mdpi.com
The aim of the study was a synthesis and investigation of the dose-dependent anti-
inflammatory effect of new thiourea derivatives of naproxen with selected aromatic amines …

Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+)(S)-naproxen derivatives

K Birgül, Y Yıldırım, HY Karasulu, E Karasulu… - European journal of …, 2020 - Elsevier
Abstract In this study,(S)-naproxen thiosemicarbazides (3a-d), 1, 2, 4-triazoles (4a-c),
triazole-thioether hybride compounds (5a-p) were synthesized and their structures (3a, 3d …

Synthesis of Cyclodextrin-based MOFs incorporating amino acid chiral ligands for chiral separation of naproxen enantiomers

Y Li, L Zhao, J Li, S Xie, N Liang - Microchemical Journal, 2023 - Elsevier
The design of adsorbent materials capable of efficiently separating chiral molecules were a
promising way to achieve selective recognition and separation of racemic enantiomers …

Synthesis of α-cyanato-α′-carbonyl sulfoxonium ylides in water

Q Zhang, C Luo, R Lai, Z Lin, P Jia, S Xu, L Guo… - Green …, 2023 - pubs.rsc.org
A new strategy for direct access to unreported α-cyanato-α′-carbonyl sulfoxonium ylides is
reported. The developed open-flask operation is a catalyst-, metal-and additive-free green …

Anticancer ruthenium (II) tris (pyrazolyl) methane complexes with bioactive co-ligands

A Gobbo, SAP Pereira, L Biancalana, S Zacchini… - Dalton …, 2022 - pubs.rsc.org
In comparison with RuII-arene compounds, the medicinal potential of homologous RuII-tpm
compounds [tpm= tris (pyrazolyl) methane] is underexplored. Pyridine, 4-pyridinemethanol …

Synthesis, computational study and biological evaluation of 9-acridinyl and 1-coumarinyl-1, 2, 3-triazole-4-yl derivatives as topoisomerase II inhibitors

GA Abdel-Hafez, AMI Mohamed… - Journal of Enzyme …, 2022 - Taylor & Francis
Topoisomerase (IIB) inhibitors have been involved in the therapies of tumour progression
and have become a major focus for the development of anticancer agents. New three …

In vivo analgesic, anti-inflammatory and molecular docking studies of S-naproxen derivatives

N Muhammad, R Khan, F Seraj, A Khan, U Ullah… - Heliyon, 2024 - cell.com
In the current studies two naproxen derivatives (NPD) were evaluated for analgesic and anti-
inflammatory properties. The acetic acid and hot plate animal models were used to screen …