The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they
encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal …

The epithelial–mesenchymal transition (EMT) confers mesenchymal properties on epithelial
cells and has been closely associated with the acquisition of aggressive traits by carcinoma …

Aberrant expression of embryonic epithelial-mesenchymal transition-inducing transcription
factors (EMT-TFs) in epithelial cells triggers EMT, neoplastic transformation, stemness, and …

Cancer is a complex multistep process involving genetic and epigenetic changes that
eventually result in the activation of oncogenic pathways and/or inactivation of tumor …

Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was
identified. Since that time, MYC research has been intense and the advances impressive …

Beneath the complexity and idiopathy of every cancer lies a limited number of'mission
critical'events that have propelled the tumour cell and its progeny into uncontrolled …

Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that lacks
targeted therapy options, and patients diagnosed with TNBC have poorer outcomes than …

Epithelial cancers make up the vast majority of cancer types and, during the transition from
benign adenoma to malignant carcinoma and metastasis, epithelial tumor cells acquire a de …

The metastatic process is highly inefficient—very few of the many cells that migrate from the
primary tumour successfully colonize distant sites. One proposed mechanism to explain this …

The life history of cancer cells encompasses a series of genetic missteps in which normal
cells are progressively transformed into tumor cells that invade surrounding tissues and …