Secreted frizzled-related proteins (SFRP) are glycoproteins containing a so-called frizzled-
like cysteine-rich domain. This domain enables them to bind to Wnt ligands or frizzled (FzD) …

Oral carcinogenesis is a complex and multifactorial process that involves cumulative genetic
and molecular alterations, leading to uncontrolled cell proliferation, impaired DNA repair …

Secreted frizzled-related protein 2 (SFRP2) is a glycoprotein with frizzled-like cysteine-rich
domain that binds with Wnt ligands or frizzled receptors to regulate Wnt signaling. SFRP2 is …

Abnormal methylation of secreted frizzled‑related proteins (SFRPs) has been observed in
various human cancer types. The loss of SFRP gene expression induces the activation of …

The knowledge about the molecular alterations which are found in head and neck
squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are …

Oral cancer is a high incidence cancer which is of major public health concern in India being
the most common cancer in males and fifth most common cancer in females in India …

Curcumin, a phytochemical derived from the rhizome of Curcuma longa, has shown
anticancer effects against a variety of tumors. In the present study, we investigated the …

Oral cavity cancer is a type of head and neck squamous cell carcinoma (HNSCC) and
contributes to significant morbidity and mortality each year. An epigenetic pathway of …

Secreted frizzled-related protein (SFRP) 2, an identified member of the SFRPs family of
molecules, is often methylated in human cancers and its down-regulation is closely related …

Clinical studies and cancer cell models emphasize the importance of targeting therapies for
oral cancer. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is highly …