Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …

From cyanobacteria to mammals, organisms have evolved timing mechanisms to adapt to
environmental changes in order to optimize survival and improve fitness. To anticipate these …

Transcriptional regulation of circadian rhythms is essential for lipid metabolic homeostasis,
disruptions of which can lead to metabolic diseases. Whether N 6-methyladenosine (m 6 A) …

Circadian rhythms are intimately linked to cellular metabolism. Specifically, the NAD+-
dependent deacetylase SIRT1, the founding member of the sirtuin family, contributes to …

The capacity for biological timekeeping arose at least three times through evolution, in
prokaryotic cyanobacteria, in cells that evolved into higher plants, and within the group of …

The timing of daily circadian behavior can be highly variable among different individuals,
and twin studies have suggested that about half of this variability is environmentally …

Neurospora crassa has been for decades a principal model for filamentous fungal genetics
and physiology as well as for understanding the mechanism of circadian clocks. Eukaryotic …

Histone-modifying enzymes are responsible for regulating transcription, recombination, DNA
repair, DNA replication, chromatid cohesion, and chromosome segregation. Fungi are …

Introduction Circadian alterations are prevalent in Alzheimer's disease (AD) and may
contribute to cognitive impairment, behavioral symptoms, and neurodegeneration …

Background While additional research is needed, a number of large epidemiological studies
show an association between circadian disruption and metabolic disorders. Specifically …