RNA splicing is a key mechanism linking genetic variation with psychiatric disorders.
Splicing profiles are particularly diverse in brain and difficult to accurately identify and …

Schizophrenia polygenic risk is plausibly manifested by complex transcriptional
dysregulation in the brain, involving networks of co-expressed and functionally related …

Background Variation in the gene encoding zinc finger binding protein 804A (ZNF804A) is
associated with schizophrenia and bipolar disorder. Evidence suggests that ZNF804A is a …

Zinc finger proteins are one of the most abundant families of proteins and present a wide
range of structures and functions. The structural zinc ion provides the correct conformation to …

Various neuropathological findings have been reported in bipolar disorder (BD). However, it
is unclear which findings are well established. To address this gap, we carried out a …

Abstract Schizophrenia's (SZ's) heritability and familial transmission have been known for
several decades; however, despite the clear evidence for a genetic component, it has been …

We outline an ambitious project to characterize the genetic and epigenetic regulation of
multiple facets of transcription in distinct brain regions across the human lifespan in samples …

Background While a variety of evidence supports a prenatal component in schizophrenia,
there are few data regarding the cell populations involved. We sought to identify cells of the …

ZNF804A (zinc-finger protein 804A) has been recognized as a schizophrenia risk gene
across multiple world populations. Its intronic single-nucleotide polymorphism (SNP) …

Genome-wide association studies (GWAS) have revealed multiple genomic loci conferring
risk of bipolar disorder (BD), providing hints for its underlying pathobiology. However, there …