The schizophrenia susceptibility gene ZNF804A confers risk of major mood disorders

J Ou, M Li, X Xiao - The World Journal of Biological Psychiatry, 2017 - Taylor & Francis
Objectives: Genome-wide association studies (GWAS) followed by independent replications
suggest that ZNF804A is a risk gene for schizophrenia (SCZ), considering the substantial …

Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis

A Wickramasinghe, AD Tulloch, RD Hayes… - Translational …, 2015 - nature.com
We sought to test the hypothesis that the rs1344706 A allele will be associated with worse
clinical outcome in first-episode psychosis. A data linkage was set up between a large …

A comprehensive metaanalysis of ZNF804A SNPs in the risk of schizophrenia among Asian populations

L Huang, K Ohi, H Chang, H Yu, L Wu… - American Journal of …, 2016 - Wiley Online Library
Common variants in ZNF804A increased the risk of schizophrenia (and bipolar disorder),
with low effect sizes in Europeans, which is in line with the polygenic nature of the illnesses …

The interaction between the ZNF804A gene and cannabis use on the risk of psychosis in a non-clinical sample

J Soler, B Arias, J Moya, MI Ibáñez, G Ortet… - Progress in Neuro …, 2019 - Elsevier
The ZNF804A gene and cannabis use are risk factors for psychosis and both have also
been associated with schizotypal traits. This study aimed to investigate: i) the association of …

Postmortem human brain genomics in neuropsychiatric disorders—how far can we go?

AE Jaffe - Current opinion in neurobiology, 2016 - Elsevier
Highlights•Large collections of human brain tissue are prevalent in neuropsychiatric
research.•Analyzing genes and their networks in the human brain can inform …

Schizophrenia risk candidate protein ZNF804A interacts with STAT2 and influences interferon-mediated gene transcription in mammalian cells

K Klockmeier, ES Ramos, T Raskó, AM Pastor… - Journal of Molecular …, 2021 - Elsevier
Previously evidence was presented that the single-nucleotide polymorphism rs1344706
located in an intronic region of the ZNF804A gene is associated with reduced transcript …

Translating genetic risk loci into molecular risk mechanisms for schizophrenia

NJ Bray, MJ Hill - Schizophrenia Bulletin, 2016 - academic.oup.com
The past decade has witnessed major advances in our understanding of the genetics of
schizophrenia. Large, consortia-led genomic studies involving thousands of patients and …

ZNF804A Variation May Affect Hippocampal-Prefrontal Resting-State Functional Connectivity in Schizophrenic and Healthy Individuals

Y Zhang, H Yan, J Liao, H Yu, S Jiang, Q Liu… - Neuroscience …, 2018 - Springer
The ZNF804A variant rs1344706 has consistently been associated with schizophrenia and
plays a role in hippocampal-prefrontal functional connectivity during working memory …

[HTML][HTML] CACNA1C (CaV1. 2) and other L-type calcium channels in the pathophysiology and treatment of psychiatric disorders: Advances from functional genomics …

PJ Harrison, SM Husain, H Lee, A De Los Angeles… - …, 2022 - Elsevier
A role for voltage-gated calcium channels (VGCCs) in psychiatric disorders has long been
postulated as part of a broader involvement of intracellular calcium signalling. However, the …

A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding

A García-Bea, I Bermudez… - Journal of …, 2017 - journals.sagepub.com
As well as being expressed as a full-length transcript, the group II metabotropic glutamate
receptor 3 (GRM3, mGlu3) gene is expressed as an mRNA isoform which lacks exon 4 …