Diagnosis and treatment of invasive candidiasis

N Barantsevich, E Barantsevich - Antibiotics, 2022 - mdpi.com
Candida species, belonging to commensal microbial communities in humans, cause
opportunistic infections in individuals with impaired immunity. Pathogens encountered in …

Invasive candidiasis: update and current challenges in the management of this mycosis in South America

FO Riera, JP Caeiro, SC Angiolini, C Vigezzi… - Antibiotics, 2022 - mdpi.com
Invasive candidiasis encompassing Candida bloodstream infections and deep-seated
candidiasis can become a persistent health problem. These infections are caused by …

Invasive candidiasis: current clinical challenges and unmet needs in adult populations

A Soriano, PM Honore, P Puerta-Alcalde… - Journal of …, 2023 - academic.oup.com
Invasive candidiasis (IC) is a serious infection caused by several Candida species, and the
most common fungal disease in hospitals in high-income countries. Despite overall …

(1 → 3)-β-d-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial

F Bloos, J Held, S Kluge, P Simon, K Kogelmann… - Intensive care …, 2022 - Springer
Purpose To investigate whether (1→ 3)-β-d-Glucan (BDG)-guidance shortens time to
antifungal therapy and thereby reduces mortality of sepsis patients with high risk of invasive …

Checkpoint inhibitors as immunotherapy for fungal infections: Promises, challenges, and unanswered questions

S Wurster, SS Watowich, DP Kontoyiannis - Frontiers in immunology, 2022 - frontiersin.org
Opportunistic fungal infections have high mortality in patients with severe immune
dysfunction. Growing evidence suggests that the immune environment of invasive fungal …

Candida albicans can foster gut dysbiosis and systemic inflammation during HIV infection

SD Zaongo, J Ouyang, S Isnard, X Zhou… - Gut …, 2023 - Taylor & Francis
Candida albicans (C. albicans) is a ubiquitous fungal commensal component of the human
microbiota, and under certain circumstances, such as during an immunocompromised state …

[HTML][HTML] Antifungal therapy of Candida biofilms: Past, present and future

OH Ajetunmobi, H Badali, JA Romo, G Ramage… - Biofilm, 2023 - Elsevier
Virtually all Candida species linked to clinical candidiasis are capable of forming highly
resistant biofilms on different types of surfaces, which poses an additional significant threat …

Friendly fungi: symbiosis with commensal Candida albicans

TY Shao, DB Haslam, RJ Bennett, SS Way - Trends in immunology, 2022 - cell.com
Mucosal tissues are constitutively colonized by a wide assortment of host-adapted microbes.
This includes the polymorphic fungus Candida albicans which is a primary target of human …

Candida auris from colonisation to candidemia: A four‐year study

JV Mulet Bayona, N Tormo Palop, C Salvador García… - Mycoses, 2023 - Wiley Online Library
Background Candida auris has become a worrisome multi‐drug resistant healthcare‐
associated pathogen due to its capacity to colonise patients and surfaces and to cause …

High-Throughput Screening of the Repurposing Hub Library to Identify Drugs with Novel Inhibitory Activity against Candida albicans and Candida auris Biofilms

OH Ajetunmobi, G Wall, B Vidal Bonifacio… - Journal of Fungi, 2023 - mdpi.com
Candidiasis is one of the most frequent nosocomial infections affecting an increasing
number of at-risk patients. Candida albicans remains the most frequent causative agent of …